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1,1,1-Trifluoroethyl-PEG4-azide

Catalog No. T13988Cas No. 1817735-35-5

111-Trifluoroethyl-PEG4-azide is a polyethylene glycol (PEG) derivative featuring a trifluoroethyl moiety and an azide functional group. It is utilized as a PROTAC linker, specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

1,1,1-Trifluoroethyl-PEG4-azide

1,1,1-Trifluoroethyl-PEG4-azide

Catalog No. T13988Cas No. 1817735-35-5
111-Trifluoroethyl-PEG4-azide is a polyethylene glycol (PEG) derivative featuring a trifluoroethyl moiety and an azide functional group. It is utilized as a PROTAC linker, specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
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Product Introduction

Bioactivity
Description
111-Trifluoroethyl-PEG4-azide is a polyethylene glycol (PEG) derivative featuring a trifluoroethyl moiety and an azide functional group. It is utilized as a PROTAC linker, specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
In vitro
PROTACs consist of two distinct ligands connected by a linker: one binds to an E3 ubiquitin ligase and the other targets a specific protein. Utilizing the intracellular ubiquitin-proteasome system, PROTACs selectively degrade these target proteins[1].
Chemical Properties
Molecular Weight301.26
FormulaC10H18F3N3O4
Cas No.1817735-35-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

1,1,1TrifluoroethylPEG4azide1,1,1-Trifluoroethyl-PEG-4-azide1,1,1-Trifluoroethyl-PEG4-azide1,1,1 Trifluoroethyl PEG4 azide
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