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mTOR kinase Inhibitor 2

Name: mTOR kinase Inhibitor 2
Brand: TargetMol
SKU: T9315
Price: 89 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T9315Cas No. 1021917-65-6

2H-Imidazo[4,5-b]pyrazin-2-one, 1,3-dihydro-6-[6-(1-hydroxy-1-methylethyl)-3-pyridinyl]-1-[(tetrahydro-2H-pyran-4-yl)methyl]- is a potent mTOR inhibitor with IC50 of 0.176 μM and >30 μM for mTOR and PI3Kα, respectively.

mTOR kinase Inhibitor 2

Purity: 99.96%

Catalog No. T9315Cas No. 1021917-65-6

Pack Size	Price	Availability
1 mg	$89	In Stock
5 mg	$202	In Stock
10 mg	$298	In Stock
25 mg	$476	In Stock
50 mg	$678	In Stock
100 mg	$912	In Stock
1 mL x 10 mM (in DMSO)	$217	In Stock

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Purity:99.96%

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COA HPLC HNMR

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Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	369.42
Formula	C₁₉H₂₃N₅O₃
Cas No.	1021917-65-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (135.35 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7069 mL	13.5347 mL	27.0695 mL	135.3473 mL
5 mM	0.5414 mL	2.7069 mL	5.4139 mL	27.0695 mL
10 mM	0.2707 mL	1.3535 mL	2.7069 mL	13.5347 mL
20 mM	0.1353 mL	0.6767 mL	1.3535 mL	6.7674 mL
50 mM	0.0541 mL	0.2707 mL	0.5414 mL	2.7069 mL
100 mM	0.0271 mL	0.1353 mL	0.2707 mL	1.3535 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

2HImidazo[4,5b]pyrazin2one, 1,3dihydro6[6(1hydroxy1methylethyl)3pyridinyl]1[(tetrahydro2Hpyran4yl)methyl]2H Imidazo[4,5 b]pyrazin 2 one, 1,3 dihydro 6 [6 (1 hydroxy 1 methylethyl) 3 pyridinyl] 1 [(tetrahydro 2H pyran 4 yl)methyl]