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12,14-Dichlorodehydroabietic acid
Catalog No. T40750Cas No. 65281-77-8
12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, exhibits potent calcium-activated potassium (BK) channel opening activity, effectively inhibits GABA-dependent chloride influx in the mammalian brain as a non-competitive antagonist of GABA A receptors, induces elevation in cytosolic free calcium levels, and promotes neurotransmitter release.
12,14-Dichlorodehydroabietic acid
Catalog No. T40750Cas No. 65281-77-8
12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, exhibits potent calcium-activated potassium (BK) channel opening activity, effectively inhibits GABA-dependent chloride influx in the mammalian brain as a non-competitive antagonist of GABA A receptors, induces elevation in cytosolic free calcium levels, and promotes neurotransmitter release.
| Pack Size | Price | Availability | Quantity |
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| 100 mg | Inquiry | Backorder | |
| 500 mg | Inquiry | Backorder |
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Bioactivity
Chemical Properties
| Description | 12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, exhibits potent calcium-activated potassium (BK) channel opening activity, effectively inhibits GABA-dependent chloride influx in the mammalian brain as a non-competitive antagonist of GABA A receptors, induces elevation in cytosolic free calcium levels, and promotes neurotransmitter release. |
| Molecular Weight | 369.33 |
| Formula | C20H26Cl2O2 |
| Cas No. | 65281-77-8 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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