Shopping Cart
- Remove All
Your shopping cart is currently empty
2-Deoxy-2-fluoro-L-fucose
😃Good
Catalog No. T41359Cas No. 70763-62-1
2-Deoxy-2-fluoro-L-fucose is a fucosylation inhibitor that inhibits the de novo synthesis of GDP-fucose in mammalian cells, effectively inhibits the proliferation of human cancer and primary endothelial cells, and has potential as an angiogenic therapeutic agent. It also inhibits fucosylation of plant cell wall polysaccharides, particularly affecting the dimerization of the pectin-like polysaccharide RG-II, thereby inhibiting root growth and cell elongation.2-Deoxy-2-fluoro-L-fucose also reduces the phosphorylation of Smad 1/5 and Smad 2 in 4T1 cells.
2-Deoxy-2-fluoro-L-fucose
😃Good
Catalog No. T41359Cas No. 70763-62-1
2-Deoxy-2-fluoro-L-fucose is a fucosylation inhibitor that inhibits the de novo synthesis of GDP-fucose in mammalian cells, effectively inhibits the proliferation of human cancer and primary endothelial cells, and has potential as an angiogenic therapeutic agent. It also inhibits fucosylation of plant cell wall polysaccharides, particularly affecting the dimerization of the pectin-like polysaccharide RG-II, thereby inhibiting root growth and cell elongation.2-Deoxy-2-fluoro-L-fucose also reduces the phosphorylation of Smad 1/5 and Smad 2 in 4T1 cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | Inquiry | 35 days | |
| 5 mg | Inquiry | 35 days | |
| 10 mg | Inquiry | 35 days | |
| 25 mg | Inquiry | 35 days |
Bulk & Custom
Add to Cart
Questions
View MoreSelect Batch
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | 2-Deoxy-2-fluoro-L-fucose is a fucosylation inhibitor that inhibits the de novo synthesis of GDP-fucose in mammalian cells, effectively inhibits the proliferation of human cancer and primary endothelial cells, and has potential as an angiogenic therapeutic agent. It also inhibits fucosylation of plant cell wall polysaccharides, particularly affecting the dimerization of the pectin-like polysaccharide RG-II, thereby inhibiting root growth and cell elongation.2-Deoxy-2-fluoro-L-fucose also reduces the phosphorylation of Smad 1/5 and Smad 2 in 4T1 cells. |
| In vitro | Methods: SIHA and CASKI cells were treated with E6-272 (15nM; 30nM, 48 hours) and apoptosis analysis was performed to evaluate the efficacy of E6-272 in inducing apoptosis in cervical cancer cells. Results: E6-272 (15nM) treatment of SIHA cells induced 27.85% early and 8.38% late apoptotic cell populations (Figure 8). E6-272 (30nM) treatment of CASKI cells showed 23.94% and 7.42% early and late apoptotic cell populations, respectively.[1] |
| Molecular Weight | 166.15 |
| Formula | C6H11FO4 |
| Cas No. | 70763-62-1 |
| Smiles | C[C@H](O)[C@@H](O)[C@@H](O)[C@H](F)C=O |
| Relative Density. | 1.335 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80.00 mg/mL (481.49 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy 2-Deoxy-2-fluoro-L-fucose | purchase 2-Deoxy-2-fluoro-L-fucose | 2-Deoxy-2-fluoro-L-fucose cost | order 2-Deoxy-2-fluoro-L-fucose | 2-Deoxy-2-fluoro-L-fucose chemical structure | 2-Deoxy-2-fluoro-L-fucose in vitro | 2-Deoxy-2-fluoro-L-fucose formula | 2-Deoxy-2-fluoro-L-fucose molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.