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20-HEDE (WIT 002) is an antagonist of 20-hydroxyeicosatetraenoic acid (20-HETE).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | Inquiry | 10-14 weeks | |
50 mg | Inquiry | 10-14 weeks | |
100 mg | Inquiry | 10-14 weeks |
Description | 20-HEDE (WIT 002) is an antagonist of 20-hydroxyeicosatetraenoic acid (20-HETE). |
Targets&IC50 | WIT 002:20-HEDE |
In vitro | WIT 002 inhibits proliferation of 786-O and 769-P renal adenocarcinoma cells, but HET0016 and WIT 002 fail to inhibit proliferation of normal renal epithelial cells RPTC[2][3]. |
In vivo | The growth of tumors is significantly suppressed by WIT 002 administered daily to athymic nude mice implanted subcutaneously with cells 786-O. Tumor growth is inhibited by 84%±128%. It is of note that in these experiments WIT 002 treatment start only after the tumor is seeded for 7-14 days and is relatively large 0.1 cm. Thus, WIT 002 is effective at arresting the growth of a fairly advanced tumor[3]. |
Alias | WIT 002 |
Molecular Weight | 324.50 |
Formula | C20H36O3 |
Cas No. | 240427-90-1 |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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