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4,4'-DIMETHOXYBENZIL

4,4'-Dimethoxybenzil (p-Anisil) is a human intestinal carboxyl esterase (hiCE) inhibitor( Ki : 70 nM).

Catalog No. T5943Cas No. 1226-42-2

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Purity:98%

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COA HNMR

4,4'-DIMETHOXYBENZIL

Catalog No. T5943Cas No. 1226-42-2

4,4'-Dimethoxybenzil (p-Anisil) is a human intestinal carboxyl esterase (hiCE) inhibitor( Ki : 70 nM).

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Pack Size	Price	Availability	Quantity
1 g	$29	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock

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Product Introduction

Bioactivity

Description	4,4'-Dimethoxybenzil (p-Anisil) is a human intestinal carboxyl esterase (hiCE) inhibitor( Ki : 70 nM).
Targets&IC50	Carboxyl esterase (human intestine):70 nM(Ki)
In vitro	HiCE inhibitors (4,4'-Dimethoxybenzil) mitigate irinotecan-induced diarrhea, thereby enhancing the anticancer efficacy of irinotecan.
Alias	p-Anisil

Chemical Properties

Molecular Weight	270.28
Formula	C₁₆H₁₄O₄
Cas No.	1226-42-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 6.25 mg/mL (23.12 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6999 mL	18.4993 mL	36.9987 mL	184.9933 mL
5 mM	0.7400 mL	3.6999 mL	7.3997 mL	36.9987 mL
10 mM	0.3700 mL	1.8499 mL	3.6999 mL	18.4993 mL
20 mM	0.1850 mL	0.9250 mL	1.8499 mL	9.2497 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

inhibit4,4' DIMETHOXYBENZILInhibitor4,4'-DIMETHOXYBENZIL4,4'DIMETHOXYBENZIL4,4'-Dimethoxybenzil