Shopping Cart
- Remove All
Your shopping cart is currently empty
5A2-SC8
Catalog No. T74450Cas No. 1857341-90-2
5A2-SC8 is an ionizable cationic lipid that is an ideal vehicle for the delivery of small RNAs, interacts with negatively charged cell membranes, and can be used for gene delivery and drug delivery.
5A2-SC8
Catalog No. T74450Cas No. 1857341-90-2
5A2-SC8 is an ionizable cationic lipid that is an ideal vehicle for the delivery of small RNAs, interacts with negatively charged cell membranes, and can be used for gene delivery and drug delivery.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $698 | In Stock | |
| 5 mg | $1,518 | In Stock | |
| 10 mg | $2,468 | In Stock | |
| 25 mg | $4,158 | In Stock | |
| 50 mg | $6,178 | In Stock | |
| 100 mg | $9,268 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreSelect Batch
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | 5A2-SC8 is an ionizable cationic lipid that is an ideal vehicle for the delivery of small RNAs, interacts with negatively charged cell membranes, and can be used for gene delivery and drug delivery. |
| In vitro | 5A2-SC8 is taken up by hepatocytes by binding to the LDL receptor (LDL-R) on the surface of hepatocytes and undergoing receptor-mediated endocytosis with the aid of a crown of surface-adsorbed ApoE protein. [2] |
| In vivo | A single dose of 75 mg/kg 5A2-SC8 administered intravenously was well tolerated in chronically ill mice with invasive hepatocellular carcinoma and did not adversely affect survival. [1] Intravenous injection of 0.5 mg/kg 5A2-SC8 was effective in crossing the first barrier of hepatic Kupffer cells and was internalized by hepatocytes after 6 hours in the presence of siFVII labeled with Cy5.5 dye. [2] |
| Molecular Weight | 1841.71 |
| Formula | C93H173N5O20S5 |
| Cas No. | 1857341-90-2 |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 80.00 mg/mL (43.44 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy 5A2-SC8 | purchase 5A2-SC8 | 5A2-SC8 cost | order 5A2-SC8 | 5A2-SC8 chemical structure | 5A2-SC8 in vivo | 5A2-SC8 in vitro | 5A2-SC8 formula | 5A2-SC8 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.