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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $416 | 5 days |
Description | 6-Hydroxybenzbromarone is the major metabolite of Benzbromarone. 6-Hydroxybenzbromarone is a protein Eyes Absent 3 (EYA3) inhibitor (IC50: 21.5 μM). It is an angiogenic agent, has strong inhibitory effects on cell migration, tubulogenesis, and angiogenic |
Targets&IC50 | EYA3:21.5 μM |
In vitro | 6-Hydroxybenzbromarone (7.5 μM; 72 hours) reduces cell proliferation by over 50%. Simultaneously, BBR and BZ treatments decrease cell viability, while other compounds tested do not affect cell viability or proliferation. 6-Hydroxybenzbromarone (7.5 μM; 1-20 hours) inhibits EC migration and tubulogenesis in HUVECs, but its impact on tube formation diminishes with high concentrations of fetal bovine serum (FBS), likely due to non-specific protein binding. |
Cell Research | Cell Line: HUVEC cells. Concentration: 7.5 μM. Incubation Time: 72 hours |
Molecular Weight | 440.08 |
Formula | C17H12Br2O4 |
Cas No. | 152831-00-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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