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6-Hydroxybenzbromarone

Name: 6-Hydroxybenzbromarone
Brand: TargetMol
SKU: T10182
Rating: 4.5 (1 reviews)

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Catalog No. T10182Cas No. 152831-00-0

6-Hydroxybenzbromarone is the major metabolite of Benzbromarone. 6-Hydroxybenzbromarone is a protein Eyes Absent 3 (EYA3) inhibitor (IC50: 21.5 μM). It is an angiogenic agent, has strong inhibitory effects on cell migration, tubulogenesis, and angiogenic sprouting.

6-Hydroxybenzbromarone

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Catalog No. T10182Cas No. 152831-00-0

Pack Size	Price	Availability	Quantity
2 mg	$416	5 days

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Product Introduction

Bioactivity

Description	6-Hydroxybenzbromarone is the major metabolite of Benzbromarone. 6-Hydroxybenzbromarone is a protein Eyes Absent 3 (EYA3) inhibitor (IC50: 21.5 μM). It is an angiogenic agent, has strong inhibitory effects on cell migration, tubulogenesis, and angiogenic
Targets&IC50	EYA3:21.5 μM
In vitro	6-Hydroxybenzbromarone (7.5 μM; 72 hours) reduces cell proliferation by over 50%. Simultaneously, BBR and BZ treatments decrease cell viability, while other compounds tested do not affect cell viability or proliferation. 6-Hydroxybenzbromarone (7.5 μM; 1-20 hours) inhibits EC migration and tubulogenesis in HUVECs, but its impact on tube formation diminishes with high concentrations of fetal bovine serum (FBS), likely due to non-specific protein binding.
Cell Research	Cell Line: HUVEC cells. Concentration: 7.5 μM. Incubation Time: 72 hours

Chemical Properties

Molecular Weight	440.08
Formula	C₁₇H₁₂Br₂O₄
Cas No.	152831-00-0
Relative Density.	1.785 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Keywords

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