Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM). Aβ42-IN-1 potently reduced Aβ42 levels with an IC 50 value of 0.091 μM in cultured cells without inhibiting CYP3A4. Aβ42-IN-1 shows a sustained pharmacokinetic profile.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 1,520.00 | |
50 mg | 10-14 weeks | $ 1,980.00 | |
100 mg | 10-14 weeks | $ 2,500.00 |
Description | Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM). Aβ42-IN-1 potently reduced Aβ42 levels with an IC 50 value of 0.091 μM in cultured cells without inhibiting CYP3A4. Aβ42-IN-1 shows a sustained pharmacokinetic profile. |
Targets&IC50 | γ-secretase modulator:0.091 µM |
In vivo | Aβ42-IN-1, administered orally at a dosage of 30 mg/kg, exhibits a favorable pharmacokinetic profile in mice and significantly decreases Aβ42 levels in both the brain and plasma by 36% and 66%, respectively. This reduction indicates its efficacy in lowering amyloid-beta peptides, although the brain/plasma ratio of the compound 1v is marginally less than that of 1a [1]. This study was conducted on 8-week-old male ddY mice, highlighting the compound's potential benefits in amyloid-beta related studies. |
Molecular Weight | 499 |
Formula | C29H27ClN4O2 |
CAS No. | 2582757-69-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Aβ42-IN-1 2582757-69-3 Others Aβ42IN1 Ab42-IN-1 Abeta42-IN-1 Aβ42 IN 1 inhibitor inhibit