Shopping Cart
- Remove All
![TargetMol](https://www.targetmol.com/storage/error/oops.webp)
Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $293 | In Stock | |
2 mg | $436 | In Stock | |
5 mg | $722 | In Stock | |
10 mg | $987 | In Stock | |
25 mg | $1,520 | In Stock | |
50 mg | $1,980 | In Stock |
Description | AS-35 is an orally effective, potent, and selective antagonist of leukotrienes, antagonizing LTC4-, LTD4-, and LTE4-induced ileum contractions with IC50 values of 8 nM, 4 nM, and 3 nM, respectively. It exhibits antiallergic activities. |
In vitro | In the trachea, the drug also antagonized LTD4- and LTE4-induced contraction with IC50 values of 10 nM and 20 nM, respectively. In isolated guinea pig preparations, AS-35 antagonized LTC4, LTD4, and LTE4-induced ileal contractions with IC50 values of 8 nM, 4 nM, and 3 nM, respectively. AS-35 does not antagonize LTC4-induced tracheal constriction in the presence of L-serine borate [1]. |
In vivo | AS-35 (p.o.) inhibits LTD4-induced increase in vascular permeability in guinea pig skin [1]. Oral administration of AS-35 also antagonized LTD4 as well as antigen-induced LT-mediated bronchoconstriction. AS-35 (0.0375 to 0.3 mg/kg, i.v.) dose-dependently antagonized bronchoconstriction induced by intravenous administration of LTC4 and LTD4 but not histamine-induced bronchoconstriction in anesthetized guinea pigs.[1] |
Molecular Weight | 420.42 |
Formula | C21H20N6O4 |
Cas No. | 108427-72-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.