Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AUNP-12 acetate is a polypeptide inhibitor of PD-1 that is equivalent to PD-1 and PD-2 in inhibiting lymphocyte proliferation and effector fuction, in addition to immune activation and antitumor activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 116.00 | |
5 mg | In stock | $ 326.00 | |
10 mg | In stock | $ 489.00 | |
25 mg | In stock | $ 798.00 | |
50 mg | In stock | $ 1,090.00 | |
100 mg | In stock | $ 1,480.00 |
Description | AUNP-12 acetate is a polypeptide inhibitor of PD-1 that is equivalent to PD-1 and PD-2 in inhibiting lymphocyte proliferation and effector fuction, in addition to immune activation and antitumor activity. |
In vitro | In vitro, AUNP-12 displayed equipotent antagonism toward PD-L1 and PD-L2 in the rescue of lymphocyte proliferation and effector functions. In human PBMC cells, AUNP-12 was also able to significantly rescue recombinant human PD-L1 and PD-L2 mediated inhibition in vitro, with average EC50 values of 63.3 nM and 44.1 nM against PD-L1 and PD-L2 respectively. [1] |
In vivo | AUNP-12 acetate rescued the proliferation in the mouse splenocyte assay system, with average EC50 values of 17 nM and 16.6 nM against rmPD-L1 and rmPD-L2 respectively. AUNP-12 (6 hours) showed a Plasma protein binding of 93.9% with plasma stability of more than 60%. AUNP-12 exhibited a half-life of 90 minutes in mouse liver microsomes. In male Balb/c mice, AUNP-12 subcutaneous injection or intravenous injection as a concentration of 3 mg/kg for its PK study. As a result, AUNP-12 shows a low volume of distribution, and the peak plasma levels reach at 0.2-0.4 hours. The absolute bioavailability of AUNP-12 is about 77% in mice. [1] |
Synonyms | AUNP-12 acetate (1353563-85-5 Free base) |
Molecular Weight | 3321.61 |
Formula | C144H230N40O50 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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AUNP-12 acetate Apoptosis Cell Cycle/Checkpoint Immunology/Inflammation PD-1/PD-L1 AUNP-12 acetate (1353563-85-5 Free base) AUNP12 acetate AUNP 12 acetate 1353563-85-5 Free base AUNP-12 Acetate AUNP12 Acetate AUNP 12 Acetate 1353563-85-5 inhibitor inhibit