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AZD2906

Name: AZD2906
Brand: TargetMol
SKU: T14374
Rating: 4.5 (1 reviews)

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Catalog No. T14374Cas No. 1034148-15-6

AZD2906, a selective glucocorticoid receptor (GR) agonist, demonstrates inhibitory concentrations (IC50s) of 2.2 nM in human GR, 0.3 nM in rat peripheral blood mononuclear cells (PBMC), 41.6 nM in human whole blood, and 7.5 nM in rat whole blood, respectively[1]. Additionally, it induces an increase in micronucleated immature erythrocytes within rat bone marrow.

AZD2906

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Catalog No. T14374Cas No. 1034148-15-6

Pack Size	Price	Availability
5 mg	$427	6-8 weeks
25 mg	$1,400	6-8 weeks
50 mg	$1,820	6-8 weeks
100 mg	$2,500	6-8 weeks

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	AZD2906, a selective glucocorticoid receptor (GR) agonist, demonstrates inhibitory concentrations (IC50s) of 2.2 nM in human GR, 0.3 nM in rat peripheral blood mononuclear cells (PBMC), 41.6 nM in human whole blood, and 7.5 nM in rat whole blood, respectively[1]. Additionally, it induces an increase in micronucleated immature erythrocytes within rat bone marrow.
Targets&IC50	GR (rat PBMC):0.3 nM, GR (human whole blood):41.6 nM, GR (human PBMC):2.2 nM, GR (rat whole blood):7.5 nM
In vitro	AZD2906 is a selective glucocorticoid receptor (GR) with IC50 values of 2.2 nM and 0.3 nM in human and rat PBMC, and 41.6 nM and 7.5 nM in human and rat whole blood, respectively[1].
In vivo	AZD2906 (5, 25, 50 mg/kg, p.o.) increases micronucleated immature erythrocytes (MIE) in the bone marrow of rats after 2 days of treatment and induces glycogen accumulation in the liver at 5 and 25 mg/kg, p.o., while causing moderate to marked cortical lymphocytic atrophy in the thymus of rats[1].

Chemical Properties

Molecular Weight	460.5
Formula	C₂₆H₂₅FN₄O₃
Cas No.	1034148-15-6
Relative Density.	1.33 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 125 mg/mL (271.44 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1716 mL	10.8578 mL	21.7155 mL	108.5776 mL
5 mM	0.4343 mL	2.1716 mL	4.3431 mL	21.7155 mL
10 mM	0.2172 mL	1.0858 mL	2.1716 mL	10.8578 mL
20 mM	0.1086 mL	0.5429 mL	1.0858 mL	5.4289 mL
50 mM	0.0434 mL	0.2172 mL	0.4343 mL	2.1716 mL
100 mM	0.0217 mL	0.1086 mL	0.2172 mL	1.0858 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Glucocorticoid receptor, Rat whole bloodGlucocorticoid receptor, Rat PBMCGlucocorticoid receptor, Human whole bloodGlucocorticoid receptor, Human PBMCAZD-2906AZD2906AZD 2906