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AZD5462
AZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer.
Catalog No. T63838Cas No. 2787501-83-9
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Purity:99.63%
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AZD5462
Catalog No. T63838Cas No. 2787501-83-9
AZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $373 | In Stock | |
| 5 mg | $895 | In Stock | |
| 10 mg | $1,270 | In Stock | |
| 25 mg | $1,980 | In Stock | |
| 50 mg | $2,780 | In Stock | |
| 100 mg | $3,520 | In Stock |
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Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | AZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer. |
| Targets&IC50 | cAMP:17 nM (EC50s), cGMP:50 nM (EC50s) |
| In vitro | AZD5462 (example 1) exhibits stimulatory activity on cAMP or cGMP production with EC50s of 17 nM and 50 nM, respectively[1]. Binding to human plasma proteins with a fraction unbound (free) rate of 4.3%, AZD5462 demonstrates stability with Clint values of 23 μL/min/mg (human liver microsomal), 4.8 μL/min/10^6 cells (human hepatocyte), and 11 μL/min/10^6 cells (rat hepatocyte)[1]. AZD5462 enhances the phosphorylation of ERK with an EC50 value of 6.3 nM[1]. |
| Molecular Weight | 544.65 |
| Formula | C30H41FN2O6 |
| Cas No. | 2787501-83-9 |
| Storage | store at low temperature | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (91.8 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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