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Apelin-13 triTFA(217082-58-1(free base))

Catalog No. T7847 CAS T7847

Apelin-13 triTFA is the endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC50 value of 0.37 nM.

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Apelin-13 triTFA(217082-58-1(free base)) Chemical Structure

Apelin-13 triTFA(217082-58-1(free base)), CAS T7847

Pack Size	Availability	Price/USD
1 mg	In stock	$ 75.00
2 mg	In stock	$ 115.00
5 mg	In stock	$ 148.00
10 mg	In stock	$ 257.00
25 mg	In stock	$ 463.00
50 mg	In stock	$ 678.00
100 mg	In stock	$ 968.00
1 mL * 10 mM (in DMSO)	In stock	$ 429.00

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Purity: 98%

Biological Description

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Description	Apelin-13 triTFA is the endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC50 value of 0.37 nM.
In vivo	Apelin-13 highly increased AQP4 expression as well as reduced neurological scores and infarct volume.?Importantly, Apelin-13 played a role of BBB protection in both types of mice by reducing BBB permeability, increased vascular endothelial growth factor, upregulated endothelial nitric oxide synthase, and downregulated inducible NOS. In morphology, we demonstrated Apelin-13 suppressed tight junction opening and endothelial cell swelling via electron microscopy detection.?Meanwhile, Apelin-13 also alleviated apoptosis of astrocytes and promoted angiogenesis[1].?Apelin 13 treatment significantly reduced infarct size, improved neurological outcomes, decreased brain edema, and inhibited cell apoptosis, oxidative stress, and neuroinflammation after I/R. Apelin 13 significantly increased the expression of Nrf2 and the phosphorylation levels of AMPK and GSK-3β[2].
Animal Research	The expression of AQP4 induced by Apelin-13 injection at 1, 3, and 7 days after middle cerebral artery occlusion.?Meanwhile, examined the effects of Apelin-13 on neurological function, infarct volume, and BBB disruption owing to cerebral ischemia in wild type mice, and tested whether such effects were AQP4 dependent by using AQP4 knock-out mice[1].

Molecular Weight	1892.89
Formula	C75H114F9N23O22S
CAS No.	T7847

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (15.85 mM)

References and Literature

1. Chu H , Yang X , Huang C , et al. Apelin-13 Protects against Ischemic Blood-Brain Barrier Damage through the Effects of Aquaporin-4[J]. Cerebrovascular Diseases, 2017:10-25. 2. Duan J , Cui J , Yang Z , et al. Neuroprotective effect of Apelin 13 on ischemic stroke by activating AMPK/GSK-3β/Nrf2 signaling[J]. Journal of Neuroinflammation, 2019, 16(1).

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library NO PAINS Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Keywords

Apelin-13 triTFA(217082-58-1(free base)) T7847 Others Apelin 13 triTFA(217082 58 1(free base)) Apelin13 triTFA(217082581(free base)) inhibitor inhibit

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