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Atogepant
🥰Excellent
Catalog No. T26682Cas No. 1374248-81-3
Alias MK8031. Atogepant, MK-8031, MK 8031, AGN-241689, AGN241689
Atogepant (MK-8031) is an orally available, selective and potent calcitonin gene-related peptide receptor (CGRP) antagonist for the study of migraine.
Atogepant
🥰Excellent
Catalog No. T26682Alias MK8031. Atogepant, MK-8031, MK 8031, AGN-241689, AGN241689Cas No. 1374248-81-3
Atogepant (MK-8031) is an orally available, selective and potent calcitonin gene-related peptide receptor (CGRP) antagonist for the study of migraine.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $169 | In Stock | |
| 5 mg | $423 | In Stock | |
| 10 mg | $627 | In Stock | |
| 25 mg | $980 | In Stock | |
| 50 mg | $1,330 | In Stock | |
| 100 mg | $1,790 | In Stock | |
| 500 mg | $3,639 | In Stock |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Atogepant (MK-8031) is an orally available, selective and potent calcitonin gene-related peptide receptor (CGRP) antagonist for the study of migraine. |
| Targets&IC50 | CGRP receptors (rat):0.7 nM (Ki), CGRP receptors (mouse):0.13 nM (Ki), CGRP (human cloned):0.026 nM, CGRP receptors (human natural):0.026 nM (Ki), CGRP receptors (dog):1.2 nM (Ki), CGRP receptors (rhesus macaque):0.009 nM (Ki), CGRP receptors (human cloned):0.015 nM (Ki), CGRP receptors (rabbit):2.1 nM (Ki) |
| In vitro | Atogepant has a CGRP IC50=0.026 nM for human clones. The binding affinities of Atogepant for human and non-human CGRP receptors were: human (cloned) Ki=0.015 nM, human (natural) Ki=0.026 nM, rhesus macaque Ki=0.009 nM, rat Ki=0.7 nM, mouse Ki=0.13 nM, rabbit Ki=2.1 nM, dog Ki=1.2 nM, respectively. [1][2] |
| In vivo | Oral administration of Atogepant to rats (at doses of 3, 10, and 30 mg/kg, respectively) once daily for 9 days showed that Atogepant effectively attenuated the abnormal facial pain induced by nitroglycerin and ameliorated the capsaicin-induced vasodilation of primate dermis in rats.[2] |
| Alias | MK8031. Atogepant, MK-8031, MK 8031, AGN-241689, AGN241689 |
| Molecular Weight | 603.52 |
| Formula | C29H23F6N5O3 |
| Cas No. | 1374248-81-3 |
| Smiles | O=C1[C@@]2(C=3C(N1)=NC=CC3)CC=4C(C2)=NC=C(C(N[C@H]5C[C@H]([C@@H](C)N(CC(F)(F)F)C5=O)C6=C(F)C(F)=CC=C6F)=O)C4 |
| Relative Density. | 1.54 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (132.56 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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