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BAY 38-7271

Catalog No. T14504 CAS 212188-60-8

BAY 38-7271 has strong neuroprotective properties.[1] BAY 38-7271 is selective and highly potent and cannabinoid CB1/CB2 receptor agonist. With Kis of 1.85 nM and 5.96 nM for recombinant human CB1 receptor and CB2 receptor, respectively.

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BAY 38-7271, CAS 212188-60-8

Pack Size	Availability	Price/USD
25 mg	10-14 weeks	$ 2,570.00
50 mg	10-14 weeks	$ 3,380.00
100 mg	10-14 weeks	$ 4,600.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

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Chemical Properties

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Description	BAY 38-7271 has strong neuroprotective properties.[1] BAY 38-7271 is selective and highly potent and cannabinoid CB1/CB2 receptor agonist. With Kis of 1.85 nM and 5.96 nM for recombinant human CB1 receptor and CB2 receptor, respectively.
Targets&IC50	CB2:5.96 nM （ki）, CB1:1.85 nM （ki）
In vitro	BAY 38-7271 shows only minor interactions at the micromolar range with other binding sites such as adenosine A3 receptor (IC50 = 7.5 μM), peripheral GABAA benzodiazepine receptor (IC50 = 971 nM), at the monoamine transporter (IC50 = 1.7 μM), and melatonin ML1 receptor (IC50 = 3.3 μM)[1].
In vivo	BAY 38-7271 (Ed50 = 0.02 mg/kg; i.v. and 0.5 mg/kg; i.p.) induces a potent and dose-de-pendent reduction in core body temperature[1]. BAY 38-7271 (1-1000 ng/kg/h; i.v. infusion; for 4 hours) shows neuroprotective efficacy in the rat SDH model[1]. BAY 38-7271 has low physical dependence liability and is not essentially different from that of other cannabinoid CB1 receptor agonists[1] and it also has neuroprotective efficacy in models of transient and permanent occlusion of the middle cerebral artery and brain edema models[1].

Molecular Weight	430.44
Formula	C20H21F3O5S
CAS No.	212188-60-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Mauler F, et al. BAY 38-7271: a novel highly selective and highly potent cannabinoid receptor agonist for the treatment of traumatic brain injury. CNS Drug Rev. 2003 Winter;9(4):343-58.

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Keywords

BAY 38-7271 212188-60-8 GPCR/G Protein Cannabinoid Receptor BAY 38 7271 BAY 387271 inhibitor inhibit

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