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Signaling PathwaysGPCR/G ProteinCannabinoid ReceptorAM281
TOPRelated productsBioactivityChemical infoStorage&SolubilityCalculator

AM281

AM281
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Purity:100%
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COA HPLC HNMR

AM281

Catalog No. T2264Cas No. 202463-68-1
AM 281, a cannabinoid antagonist, reduces neurologic dysfunction and mortality rate after cecal ligation and puncture in rats.
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
Pack SizePriceAvailabilityQuantity
1 mg$77In Stock
5 mg$182In Stock
10 mg$288In Stock
25 mg$582In Stock
50 mg$833In Stock
100 mg$1,150In Stock
500 mg$2,290In Stock
1 mL x 10 mM (in DMSO)$258In Stock
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Product Introduction

Bioactivity
Description
AM 281, a cannabinoid antagonist, reduces neurologic dysfunction and mortality rate after cecal ligation and puncture in rats.
Targets&IC50
CB2:13000 nM (IC50), CB1:9.91 nM (IC50)
Chemical Properties
Molecular Weight557.21
FormulaC21H19Cl2IN4O2
Cas No.202463-68-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 12 mg/mL (21.54 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7947 mL8.9733 mL17.9466 mL89.7328 mL
5 mM0.3589 mL1.7947 mL3.5893 mL17.9466 mL
10 mM0.1795 mL0.8973 mL1.7947 mL8.9733 mL
20 mM0.0897 mL0.4487 mL0.8973 mL4.4866 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
1 Enter information below:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

inhibitInhibitorneurotoxicitySH-SY5YCB1Cannabinoid ReceptormemoryAM-281AM281AM 281
Related Tags: buy AM281 | purchase AM281 | AM281 cost | order AM281 | AM281 chemical structure | AM281 formula | AM281 molecular weight
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