Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) with nanomolar affinity. BI-2852 is leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 118.00 | |
5 mg | In stock | $ 291.00 | |
10 mg | In stock | $ 432.00 | |
25 mg | In stock | $ 715.00 | |
50 mg | In stock | $ 987.00 | |
100 mg | In stock | $ 1,360.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 330.00 |
Description | BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) with nanomolar affinity. BI-2852 is leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells. |
Targets&IC50 | KRas (G12C):450 nM, KRas (G12C):750 nM (kd) |
In vitro | BI-2852 (Compound 1; 10 nM-10 μM; 2 hours) shows a dose-dependent pERK modulation and antiproliferative effect at EC50s of 6.7 μM and 5.8 μM in low serum and soft agar conditions in NCI-H358 cells. |
Molecular Weight | 516.59 |
Formula | C31H28N6O2 |
CAS No. | 2375482-51-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (106.47 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BI-2852 2375482-51-0 GPCR/G Protein MAPK Ras BI2852 BI 2852 inhibit Inhibitor inhibitor