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BI-2852

Catalog No. T10533 CAS 2375482-51-0

BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) with nanomolar affinity. BI-2852 is leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.

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BI-2852, CAS 2375482-51-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) with nanomolar affinity. BI-2852 is leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.
Targets&IC50	KRAS G12C:450 nM, KRAS G12C:750 nM (kd)
In vitro	BI-2852 (Compound 1; 10 nM-10 μM; 2 hours) shows a dose-dependent pERK modulation and antiproliferative effect at EC50s of 6.7 μM and 5.8 μM in low serum and soft agar conditions in NCI-H358 cells.

Molecular Weight	516.59
Formula	C31H28N6O2
CAS No.	2375482-51-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 55 mg/mL (106.47 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kessler D, et al. Drugging an undruggable pocket on KRAS. Proc Natl Acad Sci U S A. 2019 Aug 6; 116(32):15823-15829.

Related Products

Related compounds with same targets

Divarasib Compound 3344 MC 976 KRAS G12C inhibitor 5 KRas G12C inhibitor 4 KRas G12C inhibitor 2 KRas G12C inhibitor 1 KRAS inhibitor-7

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BI-2852 2375482-51-0 G蛋白偶联受体 MAPK信号通路 Ras inhibit BI 2852 Inhibitor BI2852 inhibitor

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