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BI8626

Catalog No. T14569Cas No. 1875036-75-1

BI8626 is a ubiquitin ligase HUWE1 inhibitor with protective effects against spontaneous desiccation syndrome in NOD/ShiLtj mice.BI8626 inhibits intracellular cholesterol and decreases the expression of phosphorylated ZAP-70, CD25, and other activation markers, and inhibits the proliferation of CD4 T-cells.

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Pack Size	Price	Availability
1 mg	$84	7-10 days
5 mg	$198	7-10 days
10 mg	$313	7-10 days
25 mg	$528	7-10 days
50 mg	$752	7-10 days
100 mg	$987	7-10 days
1 mL x 10 mM (in DMSO)	$226	7-10 days

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Product Introduction

Bioactivity

Description	BI8626 is a ubiquitin ligase HUWE1 inhibitor with protective effects against spontaneous desiccation syndrome in NOD/ShiLtj mice.BI8626 inhibits intracellular cholesterol and decreases the expression of phosphorylated ZAP-70, CD25, and other activation markers, and inhibits the proliferation of CD4 T-cells.
In vitro	In LS174T cells, BI8626 (0μM, 5μM, 10μM, 15μM, 20μM; 0-4 days) delayed progression through all phases of the cell cycle, with the most pronounced effect on the G1 phase[1].

Chemical Properties

Molecular Weight	440.54
Formula	C25H28N8
Cas No.	1875036-75-1

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (136.20 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2699 mL	11.3497 mL	22.6994 mL	113.4971 mL
5 mM	0.4540 mL	2.2699 mL	4.5399 mL	22.6994 mL
10 mM	0.2270 mL	1.1350 mL	2.2699 mL	11.3497 mL
20 mM	0.1135 mL	0.5675 mL	1.1350 mL	5.6749 mL
50 mM	0.0454 mL	0.2270 mL	0.4540 mL	2.2699 mL
100 mM	0.0227 mL	0.1135 mL	0.2270 mL	1.1350 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc