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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $118 | In Stock | |
5 mg | $288 | In Stock | |
10 mg | $457 | In Stock | |
25 mg | $753 | In Stock | |
50 mg | $1,060 | In Stock | |
100 mg | $1,430 | In Stock | |
500 mg | $2,860 | In Stock |
Description | Mezigdomide (CC-92480) is a potent, novel, selective and active cereblon E3 ubiquitin ligase modulator (CELMoD) that often acts as a molecular glue. Mezigdomide has antimyeloma activity. |
In vitro | Mezigdomide-induced loss of Aiolos and Ikaros in cultures of PBMCs resulted in the activation of T cells and increased production of IL-2 and IFN-γ. Mezigdomide exerts single-agent induction of apoptosis and exhibits remarkable synergy with NSC 34521. Mezigdomide is effective in CC-4047, CC-5013, and CC-220-resistant cell lines[1]. |
In vivo | Mezigdomide (1 mg/kg) showed 75% reduction in tumor volume when tumor-bearing mice were dosed orally for 21 days. Both the 3 and 10 mg/kg doses gave near maximal response in this model[2]. |
Alias | CC-92480 |
Molecular Weight | 567.61 |
Formula | C32H30FN5O4 |
Cas No. | 2259648-80-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||
Solubility Information | DMSO: 5 mg/mL (8.81 mM) | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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