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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 6-8 weeks | |
50 mg | $1,980 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | Smurf1-IN-1, a selective E3 ubiquitin protein ligase 1 (SMURF1) inhibitor, exhibits oral activity with an IC50 of 92 nM and demonstrates considerable efficacy in a rat model of pulmonary hypertension [1]. |
In vivo | Smurf1-IN-1 (Compound 38), when administered orally at doses of 1, 3, and 10 mg/kg, significantly ameliorates the condition of a rat model of pulmonary hypertension [1]. Pharmacokinetic profiling of Smurf1-IN-1 reveals a half-life (T 1/2) of 7.9 hours with intravenous administration of 1 mg/kg, and an oral bioavailability (F%) of 82% at a 3 mg/kg dosage [1]. |
Molecular Weight | 468.98 |
Formula | C24H29ClN6O2 |
Cas No. | 1824708-03-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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