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BIZ 114

Name: BIZ 114
Brand: TargetMol
SKU: T13583
Price: 30 USD
Availability: InStock
Rating: 4.5 (1 reviews)

BIZ 114 potently inhibits the TNF-α activated NF-κΒ pathway. BIZ 114 has the potential to prevent and/or treat ophthalmic disorders.

Catalog No. T13583Cas No. 2099120-74-6

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BIZ 114

Catalog No. T13583Cas No. 2099120-74-6

BIZ 114 potently inhibits the TNF-α activated NF-κΒ pathway. BIZ 114 has the potential to prevent and/or treat ophthalmic disorders.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
2 mg	$62	5 days
5 mg	$123	5 days
1 mL x 10 mM (in DMSO)	$185	5 days

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Product Introduction

Bioactivity

Description

BIZ 114 potently inhibits the TNF-α activated NF-κΒ pathway. BIZ 114 has the potential to prevent and/or treat ophthalmic disorders.

Chemical Properties

Molecular Weight	376.57
Formula	C₂₄H₄₀O₃
Cas No.	2099120-74-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 250 mg/mL (663.89 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6555 mL	13.2777 mL	26.5555 mL	132.7774 mL
5 mM	0.5311 mL	2.6555 mL	5.3111 mL	26.5555 mL
10 mM	0.2656 mL	1.3278 mL	2.6555 mL	13.2777 mL
20 mM	0.1328 mL	0.6639 mL	1.3278 mL	6.6389 mL
50 mM	0.0531 mL	0.2656 mL	0.5311 mL	2.6555 mL
100 mM	0.0266 mL	0.1328 mL	0.2656 mL	1.3278 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

BIZ-114BIZ114BIZ 114