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Bay 65-1942 free base

Catalog No. T10472L CAS 600734-02-9

Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKKβ.

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Bay 65-1942 free base Chemical Structure

Bay 65-1942 free base, CAS 600734-02-9

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

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Description	Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKKβ.
In vitro	Administering Bay 65-1942 before ischemia significantly reduces the size of left ventricular infarcts compared to controls given a placebo. This effect is evident at every measured interval, with notable reductions in the infarct-to-area-at-risk (AAR) ratio when Bay 65-1942 is administered before ischemia, at reperfusion, and after 2 hours of reperfusion, showing significant differences when compared with the placebo group (P<0.05 for each comparison). Furthermore, animals pretreated with Bay 65-1942 exhibited substantially lower creatine kinase-MB (CK-MB) levels, indicating less cardiac muscle damage, compared to those not receiving the compound prior to ischemia-reperfusion (IR), highlighting its protective role against heart tissue damage (P<0.05 vs. placebo).
In vivo	AZD6244 and BAY 65-1942 demonstrate synergistic inhibition of cell viability at the dose combination (5 μM AZD6244+10 μM BAY 65-1942), which correlates with IC75 (CI?=?0.48±0.01). AZD6244 and BAY 65-1942 treatment induces 2- and 1.3-fold caspase 3/7 activation, respectively, compared to the DMSO-treated cells. Treatment with a combination of AZD6244 plus BAY 65-1942 leads to a 3.2-fold increase in caspase 3/7 activity[2]. Inhibitors of MEK (AZD6244) and IKK (BAY 65-1942) are used at their IC50 concentrations, as determined by a 48 hour MTS assay, which achieve sufficient inhibition of kinase activity. MYL-R cells are treated for 24 hours with AZD6244 (5 μM), BAY 65-1942 (10 μM), or a combination of these inhibitors at the same concentrations. Synergism is also indicated at the IC50 (CI?=?0.56±0.09) and IC90 (CI?=?0.46±0.02) dose combinations reported by the software (CI values are the mean of three independent experiments, ± standard deviation).

Molecular Weight	395.45
Formula	C22H25N3O4
CAS No.	600734-02-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Moss NC, et al. IKKbeta inhibition attenuates myocardial injury and dysfunction following acute ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2248-53. 2. Cooper MJ, et al. Application of multiplexed kinase inhibitor beads to study kinome adaptations in drug-resistant leukemia. PLoS One. 2013 Jun 24;8(6):e66755.

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Keywords

Bay 65-1942 free base 600734-02-9 NF-Κb IκB/IKK Bay 65 1942 free base Bay 651942 free base Bay 65-1942 inhibitor inhibit

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