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JTP 0819958 - HOIPIN-1

Catalog No. T8951

JTP-0819958 is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 of 2.8 μM[1]. JTP-0819958 suppress LUBAC-mediated NF-kB activation in vitro[2].

JTP 0819958 - HOIPIN-1

JTP 0819958 - HOIPIN-1

Purity: 95.08%
Catalog No. T8951
JTP-0819958 is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 of 2.8 μM[1]. JTP-0819958 suppress LUBAC-mediated NF-kB activation in vitro[2].
Pack SizePriceAvailabilityQuantity
1 mg$33In Stock
2 mg$45In Stock
5 mg$63In Stock
10 mg$102In Stock
25 mg$233In Stock
50 mg$377In Stock
100 mg$551In Stock
500 mg$1,220In Stock
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Purity:95.08%
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Product Introduction

Bioactivity
Description
JTP-0819958 is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 of 2.8 μM[1]. JTP-0819958 suppress LUBAC-mediated NF-kB activation in vitro[2].
In vitro
JTP-0819958 inhibited the linear polyubiquitination activity by the HOIL-1L/HOIP complex, the HOIL-1L/HOIP/SHARPIN complex, and the HOIP/SHARPIN complex equally, with IC50 values of 4.4, 3.5, and 3.7μM. The inhibitory effects of JTP-0819958 on LUBAC-mediated linear ubiquitin generation and inflammatory cytokine-induced NF-κB activation were confirmed in cellular levels.
Chemical Properties
Molecular Weight304.27
FormulaC17H13NaO4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 3.04 mg/mL (10 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.2866 mL16.4328 mL32.8655 mL164.3277 mL
5 mM0.6573 mL3.2866 mL6.5731 mL32.8655 mL
10 mM0.3287 mL1.6433 mL3.2866 mL16.4328 mL

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