Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CSRM617 is a selective small molecule inhibitor of the transcription factor ONECUT2 (OC2, the main regulator of androgen receptor). The Kd in SPR analysis is 7.43 uM, which can directly bind to the OC2-HOX domain. CSRM617 induces apoptosis by cleaving the presence of Caspase-3 and PARP. CSRM617 is well tolerated in a mouse model of prostate cancer.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | CSRM617 is a selective small molecule inhibitor of the transcription factor ONECUT2 (OC2, the main regulator of androgen receptor). The Kd in SPR analysis is 7.43 uM, which can directly bind to the OC2-HOX domain. CSRM617 induces apoptosis by cleaving the presence of Caspase-3 and PARP. CSRM617 is well tolerated in a mouse model of prostate cancer. |
In vitro | CSRM617 (0.01-100 μM; 48 hours) inhibits cell growth in several PC cell lines: PC-3, 22RV1, LNCaP, C4-2 cells. CSRM617 (10-20 μM; 48 hours) induces 22Rv1 cell apoptosis, leading to concentration-dependent cell death . CSRM617 (20 μM; 72 hours) induced 22Rv1 cell apoptosis by cleaving the presence of Caspase-3 and PARP. |
Molecular Weight | 255.23 |
Formula | C10H13N3O5 |
CAS No. | 787504-88-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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CSRM617 787504-88-5 Others CSRM-617 CSRM 617 inhibitor inhibit