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Cilengitide TFA

Catalog No. T6806 CAS 199807-35-7

Cilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2.

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Cilengitide TFA, CAS 199807-35-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Cilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2.
Targets&IC50	αvβ3 receptor:4.1 nM, αvβ5 receptor:79 nM
In vitro	6-Thio-dG induces telomere dysfunction and results in progressive telomere shortening in telomerase-positive human cancer cells and hTERT-expressing human fibroblasts. In tested cancer cells, 6-thio-dG inhibits cell viability with IC50 values between 0.7 and 2.9 μM. [1]

Molecular Weight	702.689
Formula	C29H41F3N8O9
CAS No.	199807-35-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 93 mg/mL (132.4 mM)

Ethanol: <1 mg/mL

H2O: 8 mg/mL (11.38 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Nisato RE, et al. Angiogenesis, 2003, 6(2), 105-119. 2. Oliveira-Ferrer L, et al. J Exp Clin Cancer Res, 2008, 27:86. 3. Reardon DA, et al. Genes Cancer, 2011, 2(12):1159-1165.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Lung Cancer Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Cilengitide TFA 199807-35-7 细胞骨架自噬 Autophagy Integrin Inhibitor EMD121974 EMD 121974 Cilengitide EMD-121974 inhibit inhibitor

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