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E1231

Catalog No. T9106 CAS 1031195-19-3

E1231 is an activator of SIRT1 . E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.

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E1231, CAS 1031195-19-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 48.00
5 mg	In stock	$ 113.00
10 mg	In stock	$ 178.00
25 mg	In stock	$ 363.00
50 mg	In stock	$ 578.00
100 mg	In stock	$ 833.00
500 mg	In stock	$ 1,690.00
1 mL * 10 mM (in DMSO)	In stock	$ 152.00

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Purity: 98.86%

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Description	E1231 is an activator of SIRT1 . E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.
In vitro	E1231, a piperazine 1,4-diamide compound, was identified as a SIRT1 activator with EC50value of 0.83 μM. E1231 interacted with recombinant human SIRT1 protein and deacetylated liver X receptor-alpha (LXRα). E1231 increased ATP-binding cassette transporter A1 (ABCA1) expression in RAW 264.7 cells dependent on SIRT1 and LXRα. E1231 promoted cholesterol efflux and inhibited lipid accumulation in RAW 264.7 cells via SIRT1 and ABCA1. In the golden hamster hyperlipidemia model, E1231 treatment decreased total cholesterol and triglyceride levels in both serum and the liver, while increased cholesterol content in feces. Moreover, E1231 increased ABCA1 and SIRT1 protein expression in the liver. In ApoE-/-?mice, E1231 treatment reduced atherosclerotic plaque development compared with untreated ApoE-/-?mice.
Cell Research	A high-throughput screening assay was established to identify SIRT1 activators. Surface plasmon resonance and immunoprecipitation were performed to confirm the interaction of E1231 with SIRT1. Cholesterol assay was performed to demonstrate the in vitro effect of E1231. The in vivo effect of E1231 was evaluated in experimental models

Molecular Weight	363.41
Formula	C21H21N3O3
CAS No.	1031195-19-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (165.1 mM)

References and Literature

1. Feng T , Liu P , Wang X , et al. SIRT1 activator E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression[J]. Atherosclerosis, 2018:172-181.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Bioactive Compounds Library Max Histone Modification Compound Library Anti-Aging Compound Library Anti-Cancer Compound Library DNA Damage & Repair Compound Library Epigenetics Compound Library NO PAINS Compound Library

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Related compounds with same targets

SPC-180002 WAY-323061 Sirt1/2-IN-4 Z26395438 JGB1741 OSS_128167 SRT 1460 SIRT6-IN-5

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Keywords

E1231 1031195-19-3 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin E-1231 E 1231 inhibitor inhibit

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