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Eclazolast

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Purity:100%

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COA HNMR HPLC LCMS

Eclazolast

Catalog No. T25360Cas No. 80263-73-6

Eclazolast (RHC 2871) is a lipophilic anti-allergic compound that inhibits mediator release in a mast cell model.Eclazolast inhibits extracellular secretion by affecting only the direct processes associated with Fc(epsilon)RI in the cell.The effect of Eclazolast is highly dependent on the concentration of antigen that triggers the cell.

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Pack Size	Price	Availability
1 mg	$120	In Stock
5 mg	$290	In Stock
10 mg	$440	In Stock
25 mg	$728	In Stock
50 mg	$987	In Stock
100 mg	$1,390	In Stock
500 mg	$2,770	In Stock
1 mL x 10 mM (in DMSO)	$276	In Stock

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Product Introduction

Bioactivity

Description	Eclazolast (RHC 2871) is a lipophilic anti-allergic compound that inhibits mediator release in a mast cell model.Eclazolast inhibits extracellular secretion by affecting only the direct processes associated with Fc(epsilon)RI in the cell.The effect of Eclazolast is highly dependent on the concentration of antigen that triggers the cell.
In vitro	Eclazolast down-regulates IP3 levels. In contrast to lipophilic drugs, eclazolast does not affect artificial bilayers and erythrocyte membranes, and there is no effect on thapsigargin-induced Ca2+ influx. The effect of eclazolast was highly dependent on the antigen concentration with which the cells were triggered.[1]
In vivo	REV 2871 (CHBZ) was shown to be potent and orally effective inhibitors of passive cutaneous anaphylaxis (PCA) in the rat (ED50 = 12 mg/kg). In the guinea pig lung slice model, CHBZ inhibited AIR (IC50 = 800 microM).[2]
Alias	RHC2871, RHC-2871, REV2871, REV 2871, RHC 2871

Chemical Properties

Molecular Weight	269.68
Formula	C12H12ClNO4
Cas No.	80263-73-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.5 mg/mL (101.97 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7081 mL	18.5405 mL	37.0810 mL	185.4049 mL
5 mM	0.7416 mL	3.7081 mL	7.4162 mL	37.0810 mL
10 mM	0.3708 mL	1.8540 mL	3.7081 mL	18.5405 mL
20 mM	0.1854 mL	0.9270 mL	1.8540 mL	9.2702 mL
50 mM	0.0742 mL	0.3708 mL	0.7416 mL	3.7081 mL
100 mM	0.0371 mL	0.1854 mL	0.3708 mL	1.8540 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Keywords

REV-2871Eclazolast