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Fmoc-PEG6-NHS ester is a PEG-based linker for PROTACs, facilitating the formation of PROTAC molecules by joining two essential ligands. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Description | Fmoc-PEG6-NHS ester is a PEG-based linker for PROTACs, facilitating the formation of PROTAC molecules by joining two essential ligands. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. |
In vitro | PROTACs are composed of two distinct ligands linked together: one binds to an E3 ubiquitin ligase and the other to the target protein. They utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
Molecular Weight | 672.72 |
Formula | C34H44N2O12 |
Cas No. | 1818294-31-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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