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Foliglurax

Catalog No. T11311L   CAS 1883329-51-8
Synonyms: PXT002331

Foliglurax is a highly selective brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) (EC50: 79 nM).

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Foliglurax Chemical Structure
Foliglurax, CAS 1883329-51-8
Pack Size Availability Price/USD Quantity
25 mg 6-8 weeks $ 1,520.00
50 mg 6-8 weeks $ 1,980.00
100 mg 6-8 weeks $ 2,500.00
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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Foliglurax is a highly selective brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) (EC50: 79 nM).
Targets&IC50 mGlu4:79 nM (EC50)
In vitro Foliglurax is a highly selective and potent mGlu4 receptor PAM. It has a marked brain-penetrance feature, which might revolutionize the field of mGlu4 receptor drug targeting in CNS disorders [2].
Synonyms PXT002331
Molecular Weight 421.51
Formula C23H23N3O3S
CAS No. 1883329-51-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5.2 mg/mL (12.34 mM), sonification/heating is recommended.

TargetMolReferences and Literature

1. Charvin D, et al. Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4. J Med Chem. 2017 Oct 26;60(20):8515-8537. 2. Volpi C, et al. Opportunities and challenges in drug discovery targeting metabotropic glutamate receptor 4. Expert Opin Drug Discov. 2018 May;13(5):411-423.

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Keywords

Foliglurax 1883329-51-8 Neuroscience GluR PXT 002331 PXT-002331 PXT002331 inhibitor inhibit

 

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