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Fradafiban binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM. Fradafiban is a non-polypeptide platelet glycoprotein IIb/IIIa antagonist.
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Description | Fradafiban binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM. Fradafiban is a non-polypeptide platelet glycoprotein IIb/IIIa antagonist. |
Targets&IC50 | GP IIb/IIIa complex (human platelet):(kd)148 nM |
In vitro | Fradafiban binds with high affinity and selectivity to the human platelet GP IIb/IIIa complex and potently inhibits human platelet aggregation in vitro.?Fradafiban reversibly binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM.?Fradafiban is a nonpeptide mimetic of the arginine-glycine-aspartic acid recognition sequence. |
In vivo | Fradafiban exhibits limited oral activity, likely attributed to its high polarity, which results in poor absorption following oral ingestion. |
Alias | BIBU-52 |
Molecular Weight | 367.4 |
Formula | C20H21N3O4 |
Cas No. | 148396-36-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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