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GR79236

Catalog No. TQ0136 CAS 124555-18-6

Synonyms: GR 79236

GR79236 is an effective and selective adenosine A1 receptor agonist (Ki: 3.1 nM) that has analgesic and anti-inflammatory actions.

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GR79236, CAS 124555-18-6

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Purity: 98%

Biological Description

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Description	GR79236 is an effective and selective adenosine A1 receptor agonist (Ki: 3.1 nM) that has analgesic and anti-inflammatory actions.
Targets&IC50	adenosine A1 receptor:3.1 nM (cell free)
In vivo	GR79236 has been shown to have antinociceptive and anti-inflammatory properties in animal models. GR79236 inhibits the release of CGRP evoked by superior sagittal sinus (SSS) stimulation in the cat and inhibits trigeminal nucleus firing in the cat and rat. GR79236X has acute, short-term analgesic efficacy.

Synonyms	GR 79236
Molecular Weight	351.363
Formula	C15H21N5O5
CAS No.	124555-18-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: 98 mg/mL (278.92 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Sneyd JR, et al. Multicentre evaluation of the adenosine agonist GR79236X in patients with dental pain after third molar extraction. Br J Anaesth. 2007 May;98(5):672-676. 2. Arulmani U, et al. Lack of effect of the adenosine A1 receptor agonist, GR79236, on capsaicin-induced CGRP release in anaesthetized pigs. Cephalalgia. 2005 Nov;25(11):1082-90.

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Keywords

GR79236 124555-18-6 GPCR/G Protein Neuroscience Adenosine Receptor GR 79236 GR-79236 Inhibitor inhibitor inhibit

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