Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 |
Description | IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity. |
Targets&IC50 | IDO1:81 nM |
In vitro | IDO1-IN-2 has an IC50 of 249 nM for IDO1 wholr blood.IDO1-IN-2 inhibits amino-cyclobutarene-derived indoleamine-2,3-dioxygenase 1 (IDO1) Hela cellular with an IC50 of 49 nM. |
In vivo | IDO1-IN-2 exhibits pharmacokinetic properties with a half-life (t1/2) of 3.7 hours, a clearance/bioavailable unbound clearance (CL/CLu) of 15/319 mL/min/kg, and bioavailability (F) of 63% in rats. In dogs, its half-life extends to 6 hours, with a CL/CLu of 6/88 mL/min/kg, and a bioavailability of 67%. Furthermore, IDO1-IN-2, administered at a dose of 100 mg/kg twice daily, effectively enhances therapeutic outcomes when used alongside anti-PD-1 monoclonal antibodies (mAb) in a mouse EMT6 tumor syngeneic model, demonstrating significant synergy in efficacy. |
Molecular Weight | 364.33 |
Formula | C15H17FN6O4 |
CAS No. | 2346614-58-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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IDO1-IN-2 2346614-58-0 Metabolism IDO IDO1 IN 2 IDO1IN2 IDO-1-IN-2 inhibitor inhibit