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IDO1-IN-2
Catalog No. T11624Cas No. 2346614-58-0
IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity.
IDO1-IN-2
Catalog No. T11624Cas No. 2346614-58-0
IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity. |
| Targets&IC50 | IDO1:81 nM |
| In vitro | IDO1-IN-2 has an IC50 of 249 nM for IDO1 wholr blood.IDO1-IN-2 inhibits amino-cyclobutarene-derived indoleamine-2,3-dioxygenase 1 (IDO1) Hela cellular with an IC50 of 49 nM. |
| In vivo | IDO1-IN-2 exhibits pharmacokinetic properties with a half-life (t1/2) of 3.7 hours, a clearance/bioavailable unbound clearance (CL/CLu) of 15/319 mL/min/kg, and bioavailability (F) of 63% in rats. In dogs, its half-life extends to 6 hours, with a CL/CLu of 6/88 mL/min/kg, and a bioavailability of 67%. Furthermore, IDO1-IN-2, administered at a dose of 100 mg/kg twice daily, effectively enhances therapeutic outcomes when used alongside anti-PD-1 monoclonal antibodies (mAb) in a mouse EMT6 tumor syngeneic model, demonstrating significant synergy in efficacy. |
| Molecular Weight | 364.33 |
| Formula | C15H17FN6O4 |
| Cas No. | 2346614-58-0 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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