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Ilorasertib hydrochloride

Catalog No. T11638   CAS 1847485-91-9
Synonyms: ABT-348 hydrochloride

Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s: 1 nM, 7 nM, 120 nM). It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: 7 nM, 3 nM, and 32 nM).

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Ilorasertib hydrochloride Chemical Structure
Ilorasertib hydrochloride, CAS 1847485-91-9
Pack Size Availability Price/USD Quantity
2 mg 5 days $ 116.00
50 mg 6-8 weeks $ 789.00
100 mg 6-8 weeks $ 1,320.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s: 1 nM, 7 nM, 120 nM). It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: 7 nM, 3 nM, and 32 nM).
Targets&IC50 FLT3:1 nM, c-Kit:20 nM, Aurora A:120 nM, PDGFRβ:13 nM, Aurora B (Y156H):12 nM, Aurora B:7 nM, PDGFRα:11 nM, CSF1R:3 nM, Aurora C:1 nM, VEGFR1:1 nM, VEGFR3:43 nM, VEGFR2:2 nM
Synonyms ABT-348 hydrochloride
Molecular Weight 525
Formula C25H22ClFN6O2S
CAS No. 1847485-91-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 41.67 mg/mL (79.37 mM), sonification is recommended.

TargetMolReferences and Literature

1. Glaser KB, et al. Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families. J Pharmacol Exp Ther. 2012 Dec;343(3):617-27.

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Keywords

Ilorasertib hydrochloride 1847485-91-9 Cell Cycle/Checkpoint Chromatin/Epigenetic Aurora Kinase ABT348 Hydrochloride ABT 348 Hydrochloride ABT-348 Hydrochloride ABT-348 hydrochloride Ilorasertib Hydrochloride inhibitor inhibit

 

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