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Ilorasertib hydrochloride

Catalog No. T11638 CAS 1847485-91-9

Synonyms: ABT-348 hydrochloride

Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s: 1 nM, 7 nM, 120 nM). It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: 7 nM, 3 nM, and 32 nM).

Ilorasertib hydrochloride, CAS 1847485-91-9

Pack Size	Availability	Price/USD
1 mg	inquiry	82.00
5 mg	inquiry	160.00
10 mg	inquiry	258.00
50 mg	inquiry	932.00
100 mg	inquiry	1567.00
200 mg	inquiry	inquiry
500 mg	inquiry	inquiry
1 mL * 10 mM (in DMSO)	inquiry	184.00

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Purity 98.00%

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s: 1 nM, 7 nM, 120 nM). It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: 7 nM, 3 nM, and 32 nM).
Targets&IC50	Aurora C :ic50 1 nM, Aurora B :ic50 7 nM, Aurora B (Y156H) :ic50 12 nM, Aurora A :ic50 120 nM, PDGFRα :ic50 11 nM, PDGFRβ :ic50 13 nM, VEGFR1 :ic50 1 nM, VEGFR2 :ic50 2 nM, VEGFR3 :ic50 43 nM, FLT3 :ic50 1 nM, CSF-1R :ic50 3 nM, c-KIT :ic50 20 nM,

Synonyms	ABT-348 hydrochloride
Purity	98.00%
Molecular Weight	525
Formula	C25H22ClFN6O2S
CAS No.	1847485-91-9

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 41.67 mg/mL (79.37 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Glaser KB, et al. Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families. J Pharmacol Exp Ther. 2012 Dec;343(3):617-27.

Related Products

Related compounds with same targets

SP-146 Aurora Kinase Inhibitor III SNS-314 Mesylate Aurora inhibitor 1 SCH-1473759 AZD1152 MBM-17S MBM-17

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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

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