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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $64 | In Stock | |
1 mL x 10 mM (in DMSO) | $148 | 6-8 weeks |
Description | Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s: 1 nM, 7 nM, 120 nM). It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: 7 nM, 3 nM, and 32 nM). |
Targets&IC50 | c-Kit:20 nM, Aurora C:1 nM, Aurora A:120 nM, VEGFR1:1 nM, PDGFRα:11 nM, FLT3:1 nM, CSF1R:3 nM, PDGFRβ:13 nM, VEGFR3:43 nM, Aurora B (Y156H):12 nM, VEGFR2:2 nM, Aurora B:7 nM |
Alias | ABT-348 hydrochloride |
Molecular Weight | 525 |
Formula | C25H22ClFN6O2S |
Cas No. | 1847485-91-9 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 41.67 mg/mL (79.37 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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