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Cell Cycle/Checkpoint Aurora Kinase Ilorasertib hydrochloride

Ilorasertib hydrochloride

Catalog No. T11638   CAS 1847485-91-9
Synonyms: ABT-348 hydrochloride

Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s: 1 nM, 7 nM, 120 nM). It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: 7 nM, 3 nM, and 32 nM).

Ilorasertib hydrochloride, CAS 1847485-91-9
Pack Size Availability Price/USD Quantity
1 mg inquiry 82.00
5 mg inquiry 160.00
10 mg inquiry 258.00
50 mg inquiry 932.00
100 mg inquiry 1567.00
200 mg inquiry inquiry
500 mg inquiry inquiry
1 mL * 10 mM (in DMSO) inquiry 184.00
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Purity 98.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s: 1 nM, 7 nM, 120 nM). It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: 7 nM, 3 nM, and 32 nM).
Targets&IC50 Aurora C :ic50 1 nM,   Aurora B :ic50 7 nM,   Aurora B (Y156H) :ic50 12 nM,   Aurora A :ic50 120 nM,   PDGFRα :ic50 11 nM,   PDGFRβ :ic50 13 nM,   VEGFR1 :ic50 1 nM,   VEGFR2 :ic50 2 nM,   VEGFR3 :ic50 43 nM,   FLT3 :ic50 1 nM,   CSF-1R :ic50 3 nM,   c-KIT :ic50 20 nM,  
Synonyms ABT-348 hydrochloride
Purity 98.00%
Molecular Weight 525
Formula C25H22ClFN6O2S
CAS No. 1847485-91-9

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 41.67 mg/mL (79.37 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Glaser KB, et al. Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families. J Pharmacol Exp Ther. 2012 Dec;343(3):617-27.

Related Products

Related compounds with same targets
SP-146 Aurora Kinase Inhibitor III SNS-314 Mesylate Aurora inhibitor 1 SCH-1473759 AZD1152 MBM-17S MBM-17

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