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JTE-952

Catalog No. T11729 CAS 1255303-54-8

JTE-952 is a oral, potent active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis.

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JTE-952, CAS 1255303-54-8

Pack Size	Availability	Price/USD
25 mg	8-10 weeks	$ 1,680.00
50 mg	8-10 weeks	$ 2,190.00
100 mg	8-10 weeks	$ 3,100.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

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Description	JTE-952 is a oral, potent active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis.
Targets&IC50	TrkA:261 nM , CSF1R:13 nM
In vivo	JTE-952 treatment reduces the overall progression of the clinical score, including inflammation and bone erosion in mouse model of collagen-induced arthritis (CIA model).

Molecular Weight	518.6
Formula	C30H34N2O6
CAS No.	1255303-54-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Ikegashira K, et al. Optimization of an azetidine series as inhibitors of colony stimulating factor-1 receptor (CSF-1R) Type II to lead to the clinical candidate JTE-952. Bioorg Med Chem Lett. 2019 Apr 1;29(7):873-877.

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Keywords

JTE-952 1255303-54-8 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor JTE 952 JTE952 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.