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KH-CB19

KH-CB19
KH-CB19 is an effective and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4).
Catalog No. T15657Cas No. 1354037-26-5

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KH-CB19

Catalog No. T15657Cas No. 1354037-26-5

KH-CB19 is an effective and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
2 mgInquiry5 days
5 mgInquiry5 days
25 mgInquiry6-8 weeks
50 mgInquiry6-8 weeks
100 mgInquiry6-8 weeks
1 mL x 10 mM (in DMSO)Inquiry5 days
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Product Introduction

Bioactivity
Description
KH-CB19 is an effective and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4).
Targets&IC50
CLK1:19.7 nM, DYRK1A:55.2 nM, CLK3:530 nM
In vitro
KH-CB19 showed potent inhibition of CLK1 (IC50: 20 nM), and for the pure isomer KH-CB19, almost 100-fold selectivity against the CLK3 isoform. Treatment of resting cells with 10 μM KH-CB19 significantly reduced the basal expression of flTF as well as HTF. Pretreatment of cells with KH-CB19 or TG003 led to a reduction of the TNF-α-induced increase in phosphorylation of all analyzed SR proteins compared with TNF-α-stimulated controls [1].
Chemical Properties
Molecular Weight338.19
FormulaC15H13Cl2N3O2
Cas No.1354037-26-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (147.85 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9569 mL14.7846 mL29.5692 mL147.8459 mL
5 mM0.5914 mL2.9569 mL5.9138 mL29.5692 mL
10 mM0.2957 mL1.4785 mL2.9569 mL14.7846 mL
20 mM0.1478 mL0.7392 mL1.4785 mL7.3923 mL
50 mM0.0591 mL0.2957 mL0.5914 mL2.9569 mL
100 mM0.0296 mL0.1478 mL0.2957 mL1.4785 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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