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KH-CB19

Name: KH-CB19
Brand: TargetMol
SKU: T15657
Price: 54 USD
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. T15657Cas No. 1354037-26-5

KH-CB19 is an effective and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4).

KH-CB19

Catalog No. T15657Cas No. 1354037-26-5

KH-CB19 is an effective and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4).

Pack Size	Price	Availability
2 mg	Inquiry	5 days
5 mg	Inquiry	5 days
25 mg	Inquiry	6-8 weeks
50 mg	Inquiry	6-8 weeks
100 mg	Inquiry	6-8 weeks
1 mL x 10 mM (in DMSO)	Inquiry	5 days

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Product Introduction

Bioactivity

Description	KH-CB19 is an effective and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4).
Targets&IC50	CLK1:19.7 nM, DYRK1A:55.2 nM, CLK3:530 nM
In vitro	KH-CB19 showed potent inhibition of CLK1 (IC50: 20 nM), and for the pure isomer KH-CB19, almost 100-fold selectivity against the CLK3 isoform. Treatment of resting cells with 10 μM KH-CB19 significantly reduced the basal expression of flTF as well as HTF. Pretreatment of cells with KH-CB19 or TG003 led to a reduction of the TNF-α-induced increase in phosphorylation of all analyzed SR proteins compared with TNF-α-stimulated controls [1].

Chemical Properties

Molecular Weight	338.19
Formula	C₁₅H₁₃Cl₂N₃O₂
Cas No.	1354037-26-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (147.85 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9569 mL	14.7846 mL	29.5692 mL	147.8459 mL
5 mM	0.5914 mL	2.9569 mL	5.9138 mL	29.5692 mL
10 mM	0.2957 mL	1.4785 mL	2.9569 mL	14.7846 mL
20 mM	0.1478 mL	0.7392 mL	1.4785 mL	7.3923 mL
50 mM	0.0591 mL	0.2957 mL	0.5914 mL	2.9569 mL
100 mM	0.0296 mL	0.1478 mL	0.2957 mL	1.4785 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

KHCB19KH CB19KH-CB-19KH-CB19