store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LY341495 is an antagonist of metabotropic glutamate receptor (IC50s: 2.9 nM, 10 nM, 170 nM for mGluR-2, mGluR-3, mGluR-8, respectively).
Pack Size | Availability | Price/USD | Quantity |
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2 mg | In stock | $ 52.00 |
Description | LY341495 is an antagonist of metabotropic glutamate receptor (IC50s: 2.9 nM, 10 nM, 170 nM for mGluR-2, mGluR-3, mGluR-8, respectively). |
Targets&IC50 | mGluR3 (human):10 nM, mGluR8 (human):170 nM, mGluR2(human):2.9 nM |
In vivo | LY341495 (3 mg/kg, i.p., 2.5 h) -induced c-Fos expression is not altered in either KO brain. LY341495 (3.0 mg/kg) reduces Dvl-2, pGSK-3α/β, and β-catenin protein levels but Dvl-1, Dvl-3, and GSK-3α/β are unaffected in both the PFC and STR. LY341495 (0.3, 1, and 3 mg/kg, i.p.) shows a lower level of discrimination in rats[1]. LY341495 has generally the opposite effect following acute and chronic administration compared to mGlu2/3 agonist, LY379268[2]. LY341495 is almost inactive in the central extended amygdala [central nucleus of the amygdala, lateral (CeL) and bed nucleus of the stria terminalis, laterodorsal (BSTLD)] in mGluR3-KO mice[3]. |
Molecular Weight | 353.37 |
Formula | C20H19NO5 |
CAS No. | 201943-63-7 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6 mg/mL (16.98 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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LY341495 201943-63-7 Endocrinology/Hormones Androgen Receptor LY-341495 LY 341495 inhibitor inhibit