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Liraglutide

Catalog No. T6876   CAS 204656-20-2
Synonyms: Liraglutidum, Victoza, Liraglutida, NN2211

Liraglutide (Liraglutida) is a long-acting GLP-1 receptor agonist.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Liraglutide Chemical Structure
Liraglutide, CAS 204656-20-2
Pack Size Availability Price/USD Quantity
1 mg In stock $ 119.00
5 mg In stock $ 497.00
10 mg In stock $ 585.00
25 mg In stock $ 937.00
50 mg In stock $ 1,270.00
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Purity: 99.04%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Liraglutide (Liraglutida) is a long-acting GLP-1 receptor agonist.
In vitro Liraglutide attenuates induction of plasminogen activator inhibitor type-1 (PAI-1) and vascular adhesion molecule (VAM) expression in human vascular endothelial cells (hVECs) in vitro and may afford protection against endothelial cell dysfunction (ECD), an early abnormality in diabetic vascular disease. In vitro studies demonstrates GLP-1R-dependent liraglutide-mediated inhibition of stimulated PAI-1 and VAM expression[3].
In vivo In vivo studies of vascular reactivity and immunohistochemical analysis are performed in the ApoE-/- mouse model. They demonstrate significant improvement in endothelial function in liraglutide treated mice, a GLP-1R dependent effect. Liraglutide treatment also increases endothelial nitric oxide synthase (eNOS) and reduces intercellular adhesion molecule-1 (ICAM-1) expression in aortic endothelium, an effect again dependent on the GLP-1R[3]. Liraglutide reduces hyperglycemia in T2D mouse models by increasing pancreatic b cell mass through enhanced proliferation[2].
Kinase Assay Assay of ProRS activity: The prolyl tRNA synthetase domain of human EPRS (ProRS) is expressed in E.coli with a 6-his tag and purified. Enzymatic activity is assayed using incorporation of 3H Pro into the tRNA fraction essentially, except that the charged tRNA fraction is isolated by rapid batchwise binding to Mono Q sepharose and quantitated by liquid scintillation counting. For all kinetic assays, the concentration of active enzyme in the reaction is 40 nM. Similar inhibition by HF is seen using the human ProRS domain purified from bacteria and full length EPRS purified from rat liver.
Cell Research C11-STH cells are cultured to confluence at 37°C in gelatin-coated Nunclon cell culture dishes in Media-199 supplemented with penicillin/streptomycin, 20% FCS, 20 μg/ml endothelial cell growth factor and 20 μg/ml heparin. C11-STH cells are incubated under serum free conditions with liraglutide (100 nM) or the GLP-1 receptor antagonist exendin (9-39) (100 nM) alone or with 10 ng/ml TNFα for 16 h alone or in combination with liraglutide and/or exendin (9-39). ELISA assays for VCAM-1 and ICAM-1 are performed using conditioned medium from C11-STH cells to determine protein expression levels.(Only for Reference)
Synonyms Liraglutidum, Victoza, Liraglutida, NN2211
Molecular Weight 3751.25
Formula C172H265N43O51
CAS No. 204656-20-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 5 mg/mL (1.33 mM), ultrasonic and adjust pH to 8 with NaOH

TargetMolReferences and Literature

1. Bode B, et al. Am J Manag Care. 2011, 17(2 Suppl):S59-70. 2. Abdulreda MH, et al. Cell Metab. 2016, 23(3):541-6. 3. Gaspari T, et al. Diab Vasc Dis Res. 2011, 8(2):117-24.

Related compound libraries

This product is contained In the following compound libraries:
NO PAINS Compound Library ReFRAME Related Library Peptide Compound Library

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L-168049 GLP-1R modulator L7-028 GLP-1R Antagonist 1 PF-06882961 Orforglipron Teduglutide GLP-1 receptor agonist 9 citrate Glucagon-like peptide 1 (1-37), human acetate

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Keywords

Liraglutide 204656-20-2 GPCR/G Protein Glucagon Receptor NN 2211 inhibit NN-2211 Liraglutidum Inhibitor Victoza Liraglutida NN2211 GCGR inhibitor

 

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