Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NAMPT inhibitor-linker 1, a drug-linker conjugate for ADC, integrates an NAMPT inhibitor (as a payload) with a linker. In the formulation of ADC-3, it pairs with an anti-c-Kit monoclonal antibody, demonstrating strong efficacy against c-Kit expressing cell lines, specifically GIST-T1 and NCI-H526, where it exhibits IC50 values of <3 pM and 9 pM, respectively.
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Description | NAMPT inhibitor-linker 1, a drug-linker conjugate for ADC, integrates an NAMPT inhibitor (as a payload) with a linker. In the formulation of ADC-3, it pairs with an anti-c-Kit monoclonal antibody, demonstrating strong efficacy against c-Kit expressing cell lines, specifically GIST-T1 and NCI-H526, where it exhibits IC50 values of <3 pM and 9 pM, respectively. |
In vitro | ADC-3 exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC50s of <3 pM and 9 pM, respectively[1]. |
In vivo | ADC-3 (20 mg/kg, i.v. for 28 days) is tolerated, and causes tumor stasis in mice bearing GIST-T1 cells[1]. |
Molecular Weight | 668.71 |
Formula | C36H37FN6O6 |
CAS No. | 2241019-57-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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NAMPT inhibitor-linker 1 2241019-57-6 Others NAMPT inhibitorlinker 1 NAMPT inhibitor linker 1 inhibitor inhibit