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Lys-SMCC-DM1
😃Good
Catalog No. T11917Cas No. 1281816-04-3
Alias Lys-Nε-MCC-DM1
Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) is an antibody-drug conjugate (ADC) targeting human epidermal growth factor receptor 2 (HER2). It contains the microtubule polymerization inhibitor DM1 as the active metabolite, which inhibits microtubule polymerization. It is commonly used in breast cancer research.
Lys-SMCC-DM1
😃Good
Catalog No. T11917Alias Lys-Nε-MCC-DM1Cas No. 1281816-04-3
Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) is an antibody-drug conjugate (ADC) targeting human epidermal growth factor receptor 2 (HER2). It contains the microtubule polymerization inhibitor DM1 as the active metabolite, which inhibits microtubule polymerization. It is commonly used in breast cancer research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $289 | In Stock | |
| 5 mg | $691 | In Stock | |
| 10 mg | $997 | In Stock | |
| 25 mg | $1,480 | In Stock | |
| 50 mg | Inquiry | Backorder | |
| 1 mL x 10 mM (in DMSO) | $1,190 | In Stock |
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CitedSelect Batch
Purity:≥98%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) is an antibody-drug conjugate (ADC) targeting human epidermal growth factor receptor 2 (HER2). It contains the microtubule polymerization inhibitor DM1 as the active metabolite, which inhibits microtubule polymerization. It is commonly used in breast cancer research. |
| In vitro | METHODS: Lys-SMCC-DM1, DXd (1), and DXd (2) were simultaneously subjected to parallel artificial membrane permeability assay (PAMPA) using the Lys-SMCC-DM1 Freedom EVO200 system. RESULTS: Lys-SMCC-DM1 has low permeability. [1] METHODS: MDCKII/SLC46A3 dC cells were treated with Lys-SMCC-DM1 (5 µM) for 30 min, and a cellular uptake assay was performed to verify whether SLC46A3 directly transported Lys-SMCC-DM1. RESULTS: SLC46A3 directly recognized and transported Lys-SMCC-DM1 and mediated the cytotoxic effects of T-DM1. [2] |
| Alias | Lys-Nε-MCC-DM1 |
| Molecular Weight | 1103.71 |
| Formula | C53H75ClN6O15S |
| Cas No. | 1281816-04-3 |
| Smiles | C[C@]12[C@@](O1)([C@H](C)[C@@]3(C[C@](O)([C@H](OC)/C=C/C=C(\C)/CC4=CC(N(C)C(=O)C[C@@H]2OC([C@@H](N(C(CCS[C@@H]5C(=O)N(C[C@@H]6CC[C@@H](C(NCCCC[C@@H](C(O)=O)N)=O)CC6)C(=O)C5)=O)C)C)=O)=C(Cl)C(OC)=C4)NC(=O)O3)[H])[H] |
| Relative Density. | 1.36 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/ml (54.36 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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