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Mc-MMAE

Name: Mc-MMAE
Brand: TargetMol
SKU: T18312
Price: 163 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T18312Cas No. 863971-24-8

Alias Maleimidocaproyl-monomethylauristatin E

Mc-MMAE (Maleimidocaproyl-monomethylauristatin E) is a drug-linker conjugate for ADC. Mc-MMAE is a maleimidocaproyl-conjugated monomethyl auristatin E, which is a potent tubulin inhibitor.

Mc-MMAE

🥰Excellent

Catalog No. T18312Alias Maleimidocaproyl-monomethylauristatin ECas No. 863971-24-8

Mc-MMAE (Maleimidocaproyl-monomethylauristatin E) is a drug-linker conjugate for ADC. Mc-MMAE is a maleimidocaproyl-conjugated monomethyl auristatin E, which is a potent tubulin inhibitor.

Pack Size	Price	Availability
1 mg	$163	In Stock
5 mg	$349	In Stock
10 mg	$562	In Stock
25 mg	$889	In Stock
50 mg	$1,190	In Stock
100 mg	$1,590	In Stock

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Purity:≥98%

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COA LCMS HNMR

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Product Introduction

Bioactivity

Description	Mc-MMAE (Maleimidocaproyl-monomethylauristatin E) is a drug-linker conjugate for ADC. Mc-MMAE is a maleimidocaproyl-conjugated monomethyl auristatin E, which is a potent tubulin inhibitor.
In vitro	The production of maleimidocaproyl-MMAE (mc-MMAE) involves introducing maleimidocaproic acid into a dichloromethane solution containing MMAE. This process is then followed by adding diethyl cyanophosphonate and diisopropylethylamine[1].
Alias	Maleimidocaproyl-monomethylauristatin E

Chemical Properties

Molecular Weight	911.18
Formula	C₄₉H₇₈N₆O₁₀
Cas No.	863971-24-8
Smiles	CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)CCCCCN1C(=O)C=CC1=O)C(C)C
Relative Density.	1.144 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 51 mg/mL (55.97 mM)

H2O: < 0.1 mg/mL (insoluble), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0975 mL	5.4874 mL	10.9748 mL	54.8739 mL
5 mM	0.2195 mL	1.0975 mL	2.1950 mL	10.9748 mL
10 mM	0.1097 mL	0.5487 mL	1.0975 mL	5.4874 mL
20 mM	0.0549 mL	0.2744 mL	0.5487 mL	2.7437 mL
50 mM	0.0219 mL	0.1097 mL	0.2195 mL	1.0975 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc