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CL2A-SN-38

Catalog No. T17731Cas No. 1279680-68-0

CL2A-SN-38 consists of a CL2A linker and an anticancer compound, SN-38, which delivers active molecules within tumor cells and in the tumor microenvironment, often in conjunction with antibodies to make biologically active antibody-coupled reactive molecules (ADCs).

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Pack Size	Price	Availability
1 mg	$148	In Stock
5 mg	$315	In Stock
10 mg	$481	In Stock

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Product Introduction

Bioactivity

Description	CL2A-SN-38 consists of a CL2A linker and an anticancer compound, SN-38, which delivers active molecules within tumor cells and in the tumor microenvironment, often in conjunction with antibodies to make biologically active antibody-coupled reactive molecules (ADCs).
Alias	CL2A SN 38, CL2A-SN38

Chemical Properties

Molecular Weight	1480.61
Formula	C73H97N11O22
Cas No.	1279680-68-0

Storage & Solubility Information

Storage

store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (54.03 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.6754 mL	3.3770 mL	6.7540 mL	33.7699 mL
5 mM	0.1351 mL	0.6754 mL	1.3508 mL	6.7540 mL
10 mM	0.0675 mL	0.3377 mL	0.6754 mL	3.3770 mL
20 mM	0.0338 mL	0.1688 mL	0.3377 mL	1.6885 mL
50 mM	0.0135 mL	0.0675 mL	0.1351 mL	0.6754 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc