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NF546
Catalog No. T12217Cas No. 1006028-37-0
NF546 is a selective agonist of non-nucleotide P2Y11(pEC50 of 6.27).
NF546
Catalog No. T12217Cas No. 1006028-37-0
NF546 is a selective agonist of non-nucleotide P2Y11(pEC50 of 6.27).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $693 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | NF546 is a selective agonist of non-nucleotide P2Y11(pEC50 of 6.27). |
| In vitro | The selective non-nucleotide P2Y(11) agonist NF546 was identified.?NF546 had a pEC(50) of 6.27 and is relatively selective for P2Y(11) over P2Y(1), P2Y(2), P2Y(4), P2Y(6), P2Y(12), P2X(1), P2X(2), and P2X(2)-X(3).?The pA(2) of NF340 was 8.02 against ATPgammaS and 8.04 against NF546 (calcium assays).?NF546 was further tested for P2Y(11)-mediated effects in monocyte-derived dendritic cells.?Similarly to ATPgammaS, NF546 led to thrombospondin-1 secretion and inhibition of lipopolysaccharide-stimulated interleukin-12 release, whereas NF340 inhibited these effects.?Further, for the first time, it was shown that ATPgammaS or NF546 stimulation promotes interleukin 8 (IL-8) release from dendritic cells, which could be inhibited by NF340. |
| Molecular Weight | 1180.74 |
| Formula | C47H44N6Na4O17P4 |
| Cas No. | 1006028-37-0 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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