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NVX-207

Name: NVX-207
Brand: TargetMol
SKU: T16368
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T16368Cas No. 745020-66-0

NVX-207 is a derivative of betulinic acid. It has anti-cancer activity.

NVX-207

😃Good

Catalog No. T16368Cas No. 745020-66-0

NVX-207 is a derivative of betulinic acid. It has anti-cancer activity.

Pack Size	Price	Availability
5 mg	$523	6-8 weeks
25 mg	$1,520	6-8 weeks
50 mg	$1,980	6-8 weeks
100 mg	$2,500	6-8 weeks

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	NVX-207 is a derivative of betulinic acid. It has anti-cancer activity.
In vitro	NVX-207 decreases cell death via apoptosis. NVX-207 has high cytotoxicity (IC50: ranging from 7.6-8.5 μM), in the three analyzed malignant glioma cell lines. NVX-207 leads to PARP cleavage and to a decrease in Survivin expression levels under normoxic and hypoxic conditions. NVX-207 displays anti-tumor activity (mean IC50 = 3.5 μM) against various human and canine cell lines. NVX-207-induced apoptosis is associated with activation of the intrinsic apoptotic pathway via cleavage of caspases -9, -3, -7, and of poly (ADP-ribose) polymerase (PARP). NVX-207 (20 μM) induces a significantly high rate of necrosis of glioma cell lines[1][2].
In vivo	The intravenous application of NVX-207 is well tolerated in mice[1].

Chemical Properties

Molecular Weight	601.86
Formula	C₃₆H₅₉NO₆
Cas No.	745020-66-0
Relative Density.	1.14 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 125 mg/mL (207.69 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6615 mL	8.3076 mL	16.6152 mL	83.0758 mL
5 mM	0.3323 mL	1.6615 mL	3.3230 mL	16.6152 mL
10 mM	0.1662 mL	0.8308 mL	1.6615 mL	8.3076 mL
20 mM	0.0831 mL	0.4154 mL	0.8308 mL	4.1538 mL
50 mM	0.0332 mL	0.1662 mL	0.3323 mL	1.6615 mL
100 mM	0.0166 mL	0.0831 mL	0.1662 mL	0.8308 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

NVX207NVX-207NVX 207