Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nelonicline is a selective agonist of neuronal nicotinic receptors.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | Nelonicline is a selective agonist of neuronal nicotinic receptors. |
In vivo | Nelonicline (0.03 mg/kg) treatment, has no significant effect on LIDs. The effect of Nelonicline (1.0 mg/kg) is also tested for its ability to reduce LIDs at a higher dose of L-dopa (15 mg/kg)/carbidopa (3.75 mg/kg). The higher dose of L-dopa leads to greater LID scores in vehicle-treated monkeys. Nelonicline treatment reduces LIDs by 70%, after the morning dose of L-dopa and 60% after the afternoon dose. The effect of Nelonicline is most pronounced during the latter weeks, possibly because of a greater decline with continued drug treatment. Nelonicline (0.10 mg/kg)treatment, decreases LIDs by ~40%, while the 0.30 and 1.0 mg/kg Nelonicline doses decrease LIDs up to ~60%. These data indicate that Nelonicline would be useful as an antidyskinetic drug in Parkinson's disease. |
Synonyms | ABT-126 |
Molecular Weight | 313.42 |
Formula | C17H19N3OS |
CAS No. | 1026134-63-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Nelonicline 1026134-63-3 GPCR/G Protein Neuroscience Adenosine Receptor ABT126 ABT 126 ABT-126 inhibitor inhibit