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Org 25543 hydrochloride

Catalog No. T22126   CAS 495076-64-7

Org 25543 hydrochloride is a potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC50 = 16 nM for hGlyT2). Displays no activity at GlyT1 or 56 other common biological targets (≥ 100 μM), in a glycine uptake assay in CHO cells.

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Org 25543 hydrochloride Chemical Structure
Org 25543 hydrochloride, CAS 495076-64-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 97.00
2 mg In stock $ 168.00
5 mg In stock $ 217.00
10 mg In stock $ 315.00
25 mg In stock $ 529.00
50 mg In stock $ 768.00
100 mg In stock $ 1,080.00
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Purity: 99.34%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Org 25543 hydrochloride is a potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC50 = 16 nM for hGlyT2). Displays no activity at GlyT1 or 56 other common biological targets (≥ 100 μM), in a glycine uptake assay in CHO cells.
Targets&IC50 GlyT2:16 nM(human)
Molecular Weight 448.983
Formula C24H33ClN2O4
CAS No. 495076-64-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 8 mg/mL

DMSO: 40 mg/mL

TargetMolReferences and Literature

1. W L Caulfield, et al.The first potent and selective inhibitors of the glycine transporter type 2.J Med Chem . 2001 Aug 16;44(17):2679-82.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Bioactive Compound Library NO PAINS Compound Library Neuronal Signaling Compound Library Inhibitor Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets
Bitopertin (R enantiomer) Opiranserin hydrochloride ASP2535 LY2365109 hydrochloride Sarcosine ALX-1393 PF-03463275 Bitopertin

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Keywords

Org 25543 hydrochloride 495076-64-7 Neuroscience GlyT Org 25543 Hydrochloride inhibitor inhibit

 

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