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Iclepertin
🥰Excellent
Catalog No. T37089Cas No. 1421936-85-7
Alias BI-425809
Iclepertin (BI-425809) is an orally active and selective inhibitor of glycine transporter protein 1 (GlyT1).Iclepertin is used for the treatment of central nervous system disorders such as Alzheimer;s disease. Iclepertin is used for central nervous system disorders such as Alzheimer;s disease, schizophrenia and cognitive disorders.
Iclepertin
🥰Excellent
Purity: 98.93%
Catalog No. T37089Alias BI-425809Cas No. 1421936-85-7
Iclepertin (BI-425809) is an orally active and selective inhibitor of glycine transporter protein 1 (GlyT1).Iclepertin is used for the treatment of central nervous system disorders such as Alzheimer;s disease. Iclepertin is used for central nervous system disorders such as Alzheimer;s disease, schizophrenia and cognitive disorders.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $226 | In Stock | |
| 2 mg | $337 | In Stock | |
| 5 mg | $562 | In Stock | |
| 10 mg | $892 | In Stock | |
| 25 mg | $1,990 | In Stock | |
| 50 mg | $3,270 | In Stock |
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Purity:98.93%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Iclepertin (BI-425809) is an orally active and selective inhibitor of glycine transporter protein 1 (GlyT1).Iclepertin is used for the treatment of central nervous system disorders such as Alzheimer;s disease. Iclepertin is used for central nervous system disorders such as Alzheimer;s disease, schizophrenia and cognitive disorders. |
| Targets&IC50 | GLT1:5.2 mM (rat primary neurons), GLT1:5 nM (human SK-N-MC cells) |
| In vitro | As an inhibitor of GlyT1, Iclepertin has IC50 values of 5.2 nM and 5.0 nM in primary rat neurons and human SK-N-MC cells, respectively[1]. |
| In vivo | In rats, oral administration of Iclepertin (BI 425809) induces a dose-dependent increase in cerebrospinal fluid levels of glycine from 30% (0.2 mg/kg) to 78% (2 mg/kg)[1]. |
| Alias | BI-425809 |
| Molecular Weight | 512.42 |
| Formula | C20H18F6N2O5S |
| Cas No. | 1421936-85-7 |
| Smiles | [H][C@@]12C[C@@]1(CN(C2)C(=O)c1cc(ccc1O[C@H](C)C(F)(F)F)S(C)(=O)=O)c1cc(on1)C(F)(F)F |
| Relative Density. | 1.508 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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