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PAT-505

Catalog No. T12372Cas No. 1782070-22-7

PAT-505 is an orally available, selective and potent inhibitor of autologous epidermal growth factor (IC50 2 nM in Hep3B cells, 9.7 nM in human blood, 62 nM in mouse plasma).

PAT-505

PAT-505

Purity: 98.84%
Catalog No. T12372Cas No. 1782070-22-7
PAT-505 is an orally available, selective and potent inhibitor of autologous epidermal growth factor (IC50 2 nM in Hep3B cells, 9.7 nM in human blood, 62 nM in mouse plasma).
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1 mg$2998-10 weeks
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Purity:98.84%
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Product Introduction

Bioactivity
Description
PAT-505 is an orally available, selective and potent inhibitor of autologous epidermal growth factor (IC50 2 nM in Hep3B cells, 9.7 nM in human blood, 62 nM in mouse plasma).
Targets&IC50
Autotaxin (Hep3B cells):2 nM, Autotaxin (mouse plasma):62 nM, Autotaxin (human blood ):9.7 nM
In vivo
PAT-505 is an effective, selective, and non-competitive inhibitor, exhibiting significant inhibition of ATX activity in plasma and liver tissues upon oral administration. Therapeutic dosing of PAT-505 in Stelic mice model of non-alcoholic steatohepatitis (NASH) resulted in a modest but significant improvement in fibrosis, with only slight improvements in hepatocyte ballooning and liver inflammation. In choline-deficient, high-fat NASH diet model, PAT-505 treatment effectively reduced liver fibrosis, without significant effects on steatosis, hepatocyte ballooning, or inflammation[1].
Chemical Properties
Molecular Weight473.92
FormulaC23H18ClF2N3O2S
Cas No.1782070-22-7
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 30 mg/mL (63.30 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1101 mL10.5503 mL21.1006 mL105.5030 mL
5 mM0.4220 mL2.1101 mL4.2201 mL21.1006 mL
10 mM0.2110 mL1.0550 mL2.1101 mL10.5503 mL
20 mM0.1055 mL0.5275 mL1.0550 mL5.2752 mL
50 mM0.0422 mL0.2110 mL0.4220 mL2.1101 mL

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