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Paricalcitol

Catalog No. TQ0200 CAS 131918-61-1

Paricalcitol is a vitamin D receptor agonist. It is used for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure.

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Paricalcitol, CAS 131918-61-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 147.00
5 mg	In stock	$ 597.00
10 mg	In stock	$ 852.00
25 mg	In stock	$ 1,290.00
50 mg	In stock	$ 1,730.00
100 mg	In stock	$ 2,350.00

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Purity: 99.5%

Purity: 98.59%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Paricalcitol is a vitamin D receptor agonist. It is used for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure.
In vitro	Paricalcitol (30 nM; HP + PC) produces a significant reduction in calcification relative to the observed in cells in HP medium. Paricalcitol causes a reduction in the levels of nuclear β-catenin to a level similar to that observed in control cells [1].
In vivo	Paricalcitol, administered at a dosage of 300 ng/kg/day, markedly reduces Tau levels and prevents left ventricular (LV) dysfunction in mice. Furthermore, this treatment significantly lowers the mRNA expression of atrial natriuretic peptide (ANP), fibronectin, and collagen III in mice subjected to transverse aortic constriction (TAC-pari) [2].
Animal Research	After TAC or sham surgery, a subset of the mice is treated with paricalcitol which activates the VDR, at a final dose of 300 ng/kg/day. Paricalcitol is dissolved in a 95% propylene glycol and 5% ethyl alcohol solution. Mice were intraperitoneally injected with paricalcitol (or vehicle only) three times per week on Monday, Wednesday, and Friday for five consecutive weeks. An established anti-hypertrophic and anti-fibrotic treatment, namely the angiotensin II receptor blocker (ARB) losartan is also included. Previous experiments have shown it is feasible and efficacious to dissolve losartan in the drinking water at a concentration of 30 mg/kg/day; mice are treated for five consecutive weeks. So, in total eight groups are studied. Sham (n=10), TAC (n=10), Sham + losartan (Sham-los, n=10), TAC + losartan (TAC-los, n=10), Sham + paricalcitol (Sham-pari, n=10), TAC + paricalcitol (TAC-pari, n=10), Sham + paricalcitol + losartan (Sham-combi, n=10) and TAC + paricalcitol + losartan (TAC-combi, n=10) [2].

Molecular Weight	416.64
Formula	C27H44O3
CAS No.	131918-61-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

Ethanol: 12 mg/mL (38.8 mM), Sonication is recommended.

DMSO: 95 mg/mL (228.02 mM), Sonication is recommended.

References and Literature

1. Martinez-Moreno JM, et al. In vascular smooth muscle cells paricalcitol prevents phosphate-induced Wnt/beta-catenin activation. Am J Physiol Renal Physiol. 2012 Aug 8. 2. Meems LM, et al. The vitamin D receptor activator paricalcitol prevents fibrosis and diastolic dysfunction in a murine model of pressure overload. J Steroid Biochem Mol Biol. 2012 Jul 16;132(3-5):282-289.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Metabolism Compound Library Bioactive Compounds Library Max Approved Drug Library Pediatric Drug Library Anti-Cancer Compound Library

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Keywords

Paricalcitol 131918-61-1 Vitamin D receptor Vitamin D Inhibitor VD/VDR inhibit inhibitor

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