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Pentosan Polysulfate Sodium (W/W 43%)

Catalog No. T12420L   CAS 140207-93-8
Synonyms: Pentosan Polysulfate Sodium

Pentosan Polysulfate Sodium is a potent and selective anti-HIV agent.with anti-inflammatory and pro-chondrogenic properties,and used for treatment of interstitial cystitis.

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Pentosan Polysulfate Sodium (W/W 43%) Chemical Structure
Pentosan Polysulfate Sodium (W/W 43%), CAS 140207-93-8
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Pentosan Polysulfate Sodium is a potent and selective anti-HIV agent.with anti-inflammatory and pro-chondrogenic properties,and used for treatment of interstitial cystitis.
In vitro Pentosan Polysulfate Sodium suppresses NF-κB, decreases the proinflammatory actions of TNFα, and decreases high glucose and advanced glycation end products (AGEs) stimulated MCP-1 production[3].
In vivo Pentosan Polysulfate Sodium treatment preserves renal function, significantly reduces albuminuria, and markedly decreases the severity of renal lesions, including tubulointerstitial inflammation. Pentosan Polysulfate Sodium also reduces upregulation of TNFα and proinflammatory genes in aging diabetic kidneys[3].
Synonyms Pentosan Polysulfate Sodium
Molecular Weight N/A
CAS No. 140207-93-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Schuchman EH, et al. Pentosan polysulfate: a novel therapy for the mucopolysaccharidoses. PLoS One. 2013;8(1):e54459. 2. Baba M, et al. Pentosan polysulfate, a sulfated oligosaccharide, is a potent and selective anti-HIV agent in vitro. Antiviral Res. 1988 Sep;9(6):335-43. 3. Wu J, et al. Inhibition of inflammation by pentosan polysulfate impedes the development and progression of severe diabetic nephropathy in aging C57B6 mice. Lab Invest. 2011 Oct;91(10):1459-71.

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Keywords

Pentosan Polysulfate Sodium (W/W 43%) 140207-93-8 Microbiology/Virology Proteases/Proteasome HIV Protease W/W 43% Pentosan Polysulfate Sodium inhibitor inhibit

 

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